The role of myeloid cell-specific TGF-β signaling in non-small-cell lung cancer (NSCLC)-induced osteolytic bone lesion development is unknown. We used a genetically engineered mouse model, Tgfbr2LysMCre knockout (KO), which has a loss of TGF-β signaling specifically in myeloid lineage cells, and we found that the area of H1993 cell-induced osteolytic bone lesions was decreased in Tgfbr2LysMCre KO mice, relative to the area in control littermates. The bone lesion areas were correlated with tumor cell proliferation, angiogenesis, and osteoclastogenesis in the microenvironment. The smaller bone lesion area was partially rescued by bFGF, which was expressed by osteoblasts. Interestingly, bFGF was able to rescue the osteoclastogenesis,...
<div><p>Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been implicated in promoti...
TGF-b expression is increased in most cases of myeloproliferative neoplasms (MPNs); however, its con...
International audiencePrimary myelofibrosis is a myeloproliferative neoplasm that is a precursor to ...
Bone mass is maintained by continuous remodeling through repeated cycles of bone resorption by osteo...
Transforming growth factor beta (TGFβ) signaling plays an important role during osteogenesis. Howeve...
Oral squamous cell carcinoma (OSCC) frequently invades nearby bone and bone involvement determines t...
Background: Transforming growth factor-β (TGF-β) plays a key role in bone metastasis formation; we h...
AbstractFgf and Tgfβ are key regulators of bone development. It is not known, however, whether there...
BACKGROUND: Bone metastasis is common in renal cell carcinoma (RCC), and the lesions are mainly oste...
While tumoral Smad-mediated transforming growth factor β (TGFβ) signaling drives osteolytic estrogen...
Multiple myeloma (MM) expands almost exclusively in the bone marrow and generates devastating bone l...
Abstract Targeting regulatory signaling pathways that control human bone marrow stromal (skeletal or...
THE TRANSFORMING GROWTH FACTOR-β (TGF-β) FAMILY is critically involved in the development and mainte...
Background: We focused on the phenotype of non-mineralizing MG63 and mineralizing TE85 human osteosa...
Collagen triple helix repeat-containing1 (Cthrc1) has previously been implicated in osteogenic diffe...
<div><p>Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been implicated in promoti...
TGF-b expression is increased in most cases of myeloproliferative neoplasms (MPNs); however, its con...
International audiencePrimary myelofibrosis is a myeloproliferative neoplasm that is a precursor to ...
Bone mass is maintained by continuous remodeling through repeated cycles of bone resorption by osteo...
Transforming growth factor beta (TGFβ) signaling plays an important role during osteogenesis. Howeve...
Oral squamous cell carcinoma (OSCC) frequently invades nearby bone and bone involvement determines t...
Background: Transforming growth factor-β (TGF-β) plays a key role in bone metastasis formation; we h...
AbstractFgf and Tgfβ are key regulators of bone development. It is not known, however, whether there...
BACKGROUND: Bone metastasis is common in renal cell carcinoma (RCC), and the lesions are mainly oste...
While tumoral Smad-mediated transforming growth factor β (TGFβ) signaling drives osteolytic estrogen...
Multiple myeloma (MM) expands almost exclusively in the bone marrow and generates devastating bone l...
Abstract Targeting regulatory signaling pathways that control human bone marrow stromal (skeletal or...
THE TRANSFORMING GROWTH FACTOR-β (TGF-β) FAMILY is critically involved in the development and mainte...
Background: We focused on the phenotype of non-mineralizing MG63 and mineralizing TE85 human osteosa...
Collagen triple helix repeat-containing1 (Cthrc1) has previously been implicated in osteogenic diffe...
<div><p>Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been implicated in promoti...
TGF-b expression is increased in most cases of myeloproliferative neoplasms (MPNs); however, its con...
International audiencePrimary myelofibrosis is a myeloproliferative neoplasm that is a precursor to ...