Targeting the mitotic pathways of rapidly proliferating tumor cells has been an effective strategy in traditional cancer therapy. Chemotherapeutics such as taxanes and vinca alkaloids, which disrupt microtubule function, have enjoyed clinical success; however, the accompanying side effects, toxicity and multi drug resistance remain as serious concerns. The emerging classes of inhibitors targeting mitotic kinases and proteasome face their own set of challenges. It is hoped that elucidation of the regulatory interface between mitotic checkpoints, mitochondria and mitotic death will aid the development of more efficacious anti-mitotic agents and improved treatment protocols. The links between the spindle assembly checkpoint (SAC) and mitochond...
Signaling via the intrinsic (mitochondrial) pathway of apoptosis represents one of the critical sign...
Microtubule-targeting (MT) drugs taxanes and vinca alkaloids are widely used as chemotherapeutic age...
Microtubule-targeting agents (MTAs), like taxanes and vinca alkaloids, are tubulin-binding drugs tha...
Cell fate in response to an aberrant mitosis is governed by two competing networks: the spindle asse...
Microtubule-targeting (MT) drugs taxanes and vinca alkaloids are widely used as chemotherapeutic age...
Even the most recent chemotherapeutic agents are either broad acting and carry with them a high degr...
Recent efforts in cancer therapy investigations have been focused on developing a rational strategy ...
Microtubule-targeting (MT) drugs taxanes and vinca alkaloids are widely used as chemotherapeutic age...
Microtubule-targeting (MT) drugs taxanes and vinca alkaloids are widely used as chemotherapeutic age...
Microtubule-targeting (MT) drugs taxanes and vinca alkaloids are widely used as chemotherapeutic age...
Microtubule-targeting (MT) drugs taxanes and vinca alkaloids are widely used as chemotherapeutic age...
The mitotic spindle assembly checkpoint (SCP) is a signal transduction pathway that ensures proper c...
Microtubule-targeting (MT) drugs taxanes and vinca alkaloids are widely used as chemotherapeutic age...
Microtubule-targeting (MT) drugs taxanes and vinca alkaloids are widely used as chemotherapeutic age...
Microtubule-targeting (MT) drugs taxanes and vinca alkaloids are widely used as chemotherapeutic age...
Signaling via the intrinsic (mitochondrial) pathway of apoptosis represents one of the critical sign...
Microtubule-targeting (MT) drugs taxanes and vinca alkaloids are widely used as chemotherapeutic age...
Microtubule-targeting agents (MTAs), like taxanes and vinca alkaloids, are tubulin-binding drugs tha...
Cell fate in response to an aberrant mitosis is governed by two competing networks: the spindle asse...
Microtubule-targeting (MT) drugs taxanes and vinca alkaloids are widely used as chemotherapeutic age...
Even the most recent chemotherapeutic agents are either broad acting and carry with them a high degr...
Recent efforts in cancer therapy investigations have been focused on developing a rational strategy ...
Microtubule-targeting (MT) drugs taxanes and vinca alkaloids are widely used as chemotherapeutic age...
Microtubule-targeting (MT) drugs taxanes and vinca alkaloids are widely used as chemotherapeutic age...
Microtubule-targeting (MT) drugs taxanes and vinca alkaloids are widely used as chemotherapeutic age...
Microtubule-targeting (MT) drugs taxanes and vinca alkaloids are widely used as chemotherapeutic age...
The mitotic spindle assembly checkpoint (SCP) is a signal transduction pathway that ensures proper c...
Microtubule-targeting (MT) drugs taxanes and vinca alkaloids are widely used as chemotherapeutic age...
Microtubule-targeting (MT) drugs taxanes and vinca alkaloids are widely used as chemotherapeutic age...
Microtubule-targeting (MT) drugs taxanes and vinca alkaloids are widely used as chemotherapeutic age...
Signaling via the intrinsic (mitochondrial) pathway of apoptosis represents one of the critical sign...
Microtubule-targeting (MT) drugs taxanes and vinca alkaloids are widely used as chemotherapeutic age...
Microtubule-targeting agents (MTAs), like taxanes and vinca alkaloids, are tubulin-binding drugs tha...