Research progress of floppy infant syndrome

The term "floppy infant" is used for describing children presenting with muscle hypotonia at or shortly after birth. The clinical manifestation of floppy infants is skeletal muscle hypotonia, which may be caused by a lot of reasons. Primary hypotonia includes central hypotonia, peripheral hypotonia, or mixed hypotonia of both. Partial floppy infant syndrome is hereditary and rare. This article reviews the literatures, mostly retrospective studies, on etiology, clinical manifestations, auxiliary examinations, differential diagnosis, treatment and multidisciplinary management of floppy infant syndrome