Abstract Background We evaluated the incidence and spectrum of pathogenic and likely pathogenic variants of cancer susceptibility genes in BRCA1/2 mutation-negative Korean patients with a high risk for hereditary breast cancer using a comprehensive multigene panel that included 35 cancer susceptibility genes. Methods Samples from 120 patients who were negative for BRCA1/2 mutations, but had been diagnosed with breast cancer that was likely hereditary, were prospectively evaluated for the prevalence of high-penetrance and moderate-penetrance germline mutations. Results Nine patients (7.5%) had at least one pathogenic or likely pathogenic variant. Ten variants were identified in these patients: TP53 in two patients, PALB2 in three patients, B...
Importance: Rare germline genetic variants in several genes are associated with increased breast can...
Background Germline mutations of breast cancer susceptibility gene BRCA1 and BRCA2 (gBRCA1/2) are as...
Abstract Background While the majority of germline inactivating mutations in BRCA1/2 are small-scale...
BACKGROUND: We evaluated the incidence and spectrum of pathogenic and likely pathogenic variants of ...
Abstract “BRCAX” refers breast cancers occurring in women with a family history predictive of being ...
Abstract Background Breast cancer develops as a result of multiple gene mutations in combination wit...
Over the past 20 years, high-penetrance pathogenic mutations in genes BRCA1, BRCA2, TP53, PTEN, STK1...
Over the past 20 years, high-penetrance pathogenic mutations in genes BRCA1, BRCA2, TP53, PTEN, STK1...
Purpose Unclassified variants (UVs) of BRCA1 and BRCA2 genes are not defined as pathogenic for b...
Genetic testing for BRCA1 and BRCA2 is crucial in diagnosing hereditary breast and ovarian cancer sy...
Background: Breast cancer, the most prevalent malignancy in women worldwide, presents diverse onset ...
The Author(s) 2012. This article is published with open access at Springerlink.com Abstract Prevalen...
Abstract Background As a large-scale study of Koreans, we evaluated the association between BRCA mut...
Abstract Genetic testing for germline mutations in BRCA1/2 of patients with breast cancer (BC) is p...
BRCA1 and BRCA2 as important DNA repair genes have been thoroughly investigated in abundant studies....
Importance: Rare germline genetic variants in several genes are associated with increased breast can...
Background Germline mutations of breast cancer susceptibility gene BRCA1 and BRCA2 (gBRCA1/2) are as...
Abstract Background While the majority of germline inactivating mutations in BRCA1/2 are small-scale...
BACKGROUND: We evaluated the incidence and spectrum of pathogenic and likely pathogenic variants of ...
Abstract “BRCAX” refers breast cancers occurring in women with a family history predictive of being ...
Abstract Background Breast cancer develops as a result of multiple gene mutations in combination wit...
Over the past 20 years, high-penetrance pathogenic mutations in genes BRCA1, BRCA2, TP53, PTEN, STK1...
Over the past 20 years, high-penetrance pathogenic mutations in genes BRCA1, BRCA2, TP53, PTEN, STK1...
Purpose Unclassified variants (UVs) of BRCA1 and BRCA2 genes are not defined as pathogenic for b...
Genetic testing for BRCA1 and BRCA2 is crucial in diagnosing hereditary breast and ovarian cancer sy...
Background: Breast cancer, the most prevalent malignancy in women worldwide, presents diverse onset ...
The Author(s) 2012. This article is published with open access at Springerlink.com Abstract Prevalen...
Abstract Background As a large-scale study of Koreans, we evaluated the association between BRCA mut...
Abstract Genetic testing for germline mutations in BRCA1/2 of patients with breast cancer (BC) is p...
BRCA1 and BRCA2 as important DNA repair genes have been thoroughly investigated in abundant studies....
Importance: Rare germline genetic variants in several genes are associated with increased breast can...
Background Germline mutations of breast cancer susceptibility gene BRCA1 and BRCA2 (gBRCA1/2) are as...
Abstract Background While the majority of germline inactivating mutations in BRCA1/2 are small-scale...