Circulating microRNAs in patients with intracranial aneurysms.

John A L Meeuwsen
Femke N G van T Hof
Wouter van Rheenen
Gabriel J E Rinkel
Jan H Veldink
Ynte M Ruigrok

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Publication date

January 2017

DOI

10.1371/journal.pone.0176558

Publisher

Public Library of Science (PLoS)

Journal

PLoS ONE

Abstract

INTRODUCTION:We compared circulating microRNA (miRNA) levels in plasma of patients with intracranial aneurysms (IA) to those of controls as a first step towards finding potential biomarkers for individuals at high risk of IA development and its subsequent rupture. PATIENTS AND METHODS:Using a PCR array we measured 370 miRNAs in plasma of 15 patients with prior aneurysmal subarachnoid hemorrhage (aSAH), of whom 11 had an additional unruptured IA (UIA), and of 15 controls. MiRNAs with a difference in levels with an absolute fold change (FC) > 1.2 and p1.2 and p<0.05). We used receiver operating characteristic (ROC) curves to illustrate the diagnostic potential of these miRNAs. RESULTS:Three of five miRNAs with a difference in levels in the PC...