Inter-molecular epitope spreading during autoimmune pathogenesis leads to generation of new pathogenic epitopes on other autoantigens beyond the original one. It raises an important question as whether autoimmunity extends beyond the target tissues if new epitopes are on the molecules shared with other tissues. This study is aimed addressing this question in a rat anti-glomerular basement membrane (GBM) glomerulonephritis model induced by a T cell epitope of glomerulus-specific collagen4α3. We have demonstrated inter-molecular B cell epitope spreading. Four novel epitopes were first identified by screening a phage display random peptide library against autoantibodies isolated from the GBM of immunized rats. All four epitopes were derived fr...
Objective Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is sometimes compl...
The autoantigen of anti-glomerular basement membrane (GBM) disease has been identified as the non-co...
Experimental autoimmune Goodpasture's disease: A pathogenetic role for both effector cells and antib...
This group previously identified a peptide p13 of alpha 3(IV)NC1 domain of type IV collagen that ind...
Goodpasture's epitope in development of experimental autoimmune glomerulonephritis in rats. The Good...
T-cell epitope of α3 chain of type IV collagen induces severe glomerulonephritis.BackgroundAnti-glom...
Goodpasture antigen, the non-collagenous domain of 3 chain of type IV collagen [3(IV)NC1], is the ta...
Anti-Glomerular Basement Membrane Glomerulonephritis (anti-GBM GM) is one of the earliest described ...
Glomerulonephritis was induced in mice by the repeated injection ofhuman glomeruli or purified glome...
Direct immunofluorescence detection of autoantibody in renal tissues in rats immunized with identifi...
Anti-Glomerular Basement Membrane Glomerulonephritis (anti-GBM GM) is one of the earliest described ...
'Autoantigen complementarity' is a theory proposing that the initiator of an autoimmune response is ...
Anti-glomerular basement membrane (GBM) autoantibodies are pathogenic in the development of anti-GBM...
Anti-glomerular basement membrane (GBM) autoantibodies are pathogenic in the development of anti-GBM...
Glomerulonephritis was induced in mice by the repeated injection of human glomeruli or purified glom...
Objective Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is sometimes compl...
The autoantigen of anti-glomerular basement membrane (GBM) disease has been identified as the non-co...
Experimental autoimmune Goodpasture's disease: A pathogenetic role for both effector cells and antib...
This group previously identified a peptide p13 of alpha 3(IV)NC1 domain of type IV collagen that ind...
Goodpasture's epitope in development of experimental autoimmune glomerulonephritis in rats. The Good...
T-cell epitope of α3 chain of type IV collagen induces severe glomerulonephritis.BackgroundAnti-glom...
Goodpasture antigen, the non-collagenous domain of 3 chain of type IV collagen [3(IV)NC1], is the ta...
Anti-Glomerular Basement Membrane Glomerulonephritis (anti-GBM GM) is one of the earliest described ...
Glomerulonephritis was induced in mice by the repeated injection ofhuman glomeruli or purified glome...
Direct immunofluorescence detection of autoantibody in renal tissues in rats immunized with identifi...
Anti-Glomerular Basement Membrane Glomerulonephritis (anti-GBM GM) is one of the earliest described ...
'Autoantigen complementarity' is a theory proposing that the initiator of an autoimmune response is ...
Anti-glomerular basement membrane (GBM) autoantibodies are pathogenic in the development of anti-GBM...
Anti-glomerular basement membrane (GBM) autoantibodies are pathogenic in the development of anti-GBM...
Glomerulonephritis was induced in mice by the repeated injection of human glomeruli or purified glom...
Objective Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is sometimes compl...
The autoantigen of anti-glomerular basement membrane (GBM) disease has been identified as the non-co...
Experimental autoimmune Goodpasture's disease: A pathogenetic role for both effector cells and antib...