Caenorhabditis elegans NRF (NF-E2-related factor)/CNC (Cap'n'collar) transcription factor, Skinhead-1 (SKN-1), is conservatively critical for promoting phase II detoxification gene expressions in response to oxidative stress. SKN-1 activity is controlled by well-known phosphorylation and recently-reported O-GlcNAcylation. Whether other kinds of posttanslational modifications of SKN-1 occur and influence its function remains elusive. Here, we found arginines 484 and 516 (R484/R516) of SKN-1 were asymmetrically dimethylated by PRMT-1. Oxidative stress enhanced the binding of PRMT-1 to SKN-1. Consequently, asymmetrical dimethylation of arginines on SKN-1 was elevated. Loss of prmt-1 or disruption of R484/R516 dimethylation decreased the enrich...
SKN-1 (protein Skinhead-1) plays a central role in promoting C. elegans longevity. The human ortholo...
Oxidative stress causes damage to cells by creating reactive oxygen species (ROS) and the overproduc...
Reactive oxygen species (ROS) play important signaling roles in metazoans, but also cause significan...
The deleterious potential to generate oxidative stress and damage is a fundamental challenge to meta...
Protein arginine methyltransferases (PRMTs) are a family of enzymes which help to mediate a number o...
Cellular damage caused by reactive oxygen species (ROS) is believed to be a major contributor to age...
2015-07-09The Nrf2 transcription factor plays a critical role in mediating adaptive responses to cel...
SKN-1/Nrf are the primary antioxidant/detoxification response transcription factors in animals and t...
In C. elegans, the skn-1 gene encodes a transcription factor that resembles mammalian Nrf2 and activ...
Studies in model organisms have identified regulatory processes that profoundly influence aging, ma...
Reactive oxygen species are chemically reactive molecules that are crucial for many cellular functio...
The overproduction of reactive oxygen species (ROS) in cells can lead to the development of diseases...
The transcription factor SKN-1, the C. elegans ortholog of mammalian Nrf protein, is a well-known lo...
In C. elegans, the SKN-1/Nrf transcription factor is a crucial component for controlling responses t...
SummaryArginine methylation is a widespread posttranslational modification of proteins catalyzed by ...
SKN-1 (protein Skinhead-1) plays a central role in promoting C. elegans longevity. The human ortholo...
Oxidative stress causes damage to cells by creating reactive oxygen species (ROS) and the overproduc...
Reactive oxygen species (ROS) play important signaling roles in metazoans, but also cause significan...
The deleterious potential to generate oxidative stress and damage is a fundamental challenge to meta...
Protein arginine methyltransferases (PRMTs) are a family of enzymes which help to mediate a number o...
Cellular damage caused by reactive oxygen species (ROS) is believed to be a major contributor to age...
2015-07-09The Nrf2 transcription factor plays a critical role in mediating adaptive responses to cel...
SKN-1/Nrf are the primary antioxidant/detoxification response transcription factors in animals and t...
In C. elegans, the skn-1 gene encodes a transcription factor that resembles mammalian Nrf2 and activ...
Studies in model organisms have identified regulatory processes that profoundly influence aging, ma...
Reactive oxygen species are chemically reactive molecules that are crucial for many cellular functio...
The overproduction of reactive oxygen species (ROS) in cells can lead to the development of diseases...
The transcription factor SKN-1, the C. elegans ortholog of mammalian Nrf protein, is a well-known lo...
In C. elegans, the SKN-1/Nrf transcription factor is a crucial component for controlling responses t...
SummaryArginine methylation is a widespread posttranslational modification of proteins catalyzed by ...
SKN-1 (protein Skinhead-1) plays a central role in promoting C. elegans longevity. The human ortholo...
Oxidative stress causes damage to cells by creating reactive oxygen species (ROS) and the overproduc...
Reactive oxygen species (ROS) play important signaling roles in metazoans, but also cause significan...