To cope with intrinsic and environmental stress, cancer cells rely on adaptive pathways more than non-transformed counterparts. Such non-oncogene addiction offers new therapeutic targets and strategies to overcome chemoresistance. In an attempt to study the role of adaptive pathways in acquired drug resistance in carcinoma cells, we devised a model of in vitro conditioning to three standard chemotherapeutic agents, cisplatin, 5-fluorouracil, and docetaxel, from the epithelial cancer cell line, HEp-2, and investigated the mechanisms underlying reduced drug sensitivity. We found that triple-resistant cells suffered from higher levels of oxidative stress, and showed heightened anti-stress responses, including the antioxidant Nrf2 pathway and a...
The phosphoinositol-3 kinase (PI3K) pathway is highly dysregulated in squamous cell carcinoma of the...
Recent advances in experimental technologies and cancer models have made possible to demonstrate tha...
Background: For the past 30 years, long-term survival rates in metastatic and recurrent osteosarcoma...
<div><p>To cope with intrinsic and environmental stress, cancer cells rely on adaptive pathways more...
Development of chemoresistance, which limits the efficiency of anticancer agents, has long been a ma...
Allelic loss of the essential autophagy gene beclin1 occurs in human cancers and renders mice tumor-...
Resistance to current chemo- and radiation therapy is the principal problem in anticancer treatment....
SummaryAllelic loss of the essential autophagy gene beclin1 occurs in human cancers and renders mice...
Autophagy is a lysosomal degradation pathway that can sequester cytosolic material, including organe...
Adaptor proteins participate in selective autophagy, which is critical for cellular detoxification a...
Autophagy and the Keap1–Nrf2 system are major cellular defense mechanisms against metabolic and oxid...
Resistance to cisplatin is a major challenge in the current cancer therapy. In order to explore new ...
Autophagy, hallmarked by the formation of double-membrane bound organelles known as autophagosomes, ...
The tumor cells have some metabolic characteristics of the original tissues, and the metabolism of t...
Background: Macroautophagy is a catabolic process that can mediate cell death or survival. Apo2 liga...
The phosphoinositol-3 kinase (PI3K) pathway is highly dysregulated in squamous cell carcinoma of the...
Recent advances in experimental technologies and cancer models have made possible to demonstrate tha...
Background: For the past 30 years, long-term survival rates in metastatic and recurrent osteosarcoma...
<div><p>To cope with intrinsic and environmental stress, cancer cells rely on adaptive pathways more...
Development of chemoresistance, which limits the efficiency of anticancer agents, has long been a ma...
Allelic loss of the essential autophagy gene beclin1 occurs in human cancers and renders mice tumor-...
Resistance to current chemo- and radiation therapy is the principal problem in anticancer treatment....
SummaryAllelic loss of the essential autophagy gene beclin1 occurs in human cancers and renders mice...
Autophagy is a lysosomal degradation pathway that can sequester cytosolic material, including organe...
Adaptor proteins participate in selective autophagy, which is critical for cellular detoxification a...
Autophagy and the Keap1–Nrf2 system are major cellular defense mechanisms against metabolic and oxid...
Resistance to cisplatin is a major challenge in the current cancer therapy. In order to explore new ...
Autophagy, hallmarked by the formation of double-membrane bound organelles known as autophagosomes, ...
The tumor cells have some metabolic characteristics of the original tissues, and the metabolism of t...
Background: Macroautophagy is a catabolic process that can mediate cell death or survival. Apo2 liga...
The phosphoinositol-3 kinase (PI3K) pathway is highly dysregulated in squamous cell carcinoma of the...
Recent advances in experimental technologies and cancer models have made possible to demonstrate tha...
Background: For the past 30 years, long-term survival rates in metastatic and recurrent osteosarcoma...