Influenza has a major impact on the elderly due to increased susceptibility to infection with age and poor response to current vaccines. We have studied universal influenza vaccine candidates based on influenza A nucleoprotein and matrix 2 (A/NP+M2). Long-lasting protection against influenza virus strains of divergent subtypes is induced, especially with mucosal immunization. Here, we tested universal vaccination in BALB/c mice of different ages. Vaccination used intramuscular DNA priming to A/NP+M2 followed by intranasal (i.n.) boosting with recombinant adenoviruses (rAd) expressing the same antigens, or only A/NP+M2-rAd given i.n. Antigen-specific systemic antibody responses were induced in young, middle-aged, and elderly mice (2, 11-17, ...
Immunosenescence is believed to be responsible for poor vaccine efficacy in the elderly. To overcome...
Background: Current influenza vaccines have reduced immunogenicity and are of uncertain efficacy in ...
Parenteral immunization of BALB/c mice at 3 months of age with inactivated influenza virus vaccine e...
The ability to resist infection and respond to vaccination is severly compromised in the elderly owi...
<div><p>Current yearly influenza virus vaccines induce strain-specific neutralizing antibody (NAb) r...
Several studies have shown a reduced efficacy of influenza vaccines in the elderly compared to young...
Age affects the immune response to vaccination, with individuals at the extremes of age responding p...
BackgroundThe elderly are at high risk from influenza, in part because immunity wanes with age and t...
Influenza viruses cause severe illnesses and death, mainly in the aged population. Protection afford...
The immunogenicity and protective efficacy of a DNA vaccine encoding the circumsporozoite protein of...
Elderly people are at high risk for influenza-related morbidity and mortality due to progressive imm...
BackgroundThe elderly are at high risk from influenza, in part because immunity wanes with age and t...
Influenza causes serious and sometimes fatal disease in individuals at risk due to advanced age or i...
Several studies have shown a reduced efficacy of influenza vaccines in the elderly compared to young...
Background: T-cell responses against highly conserved influenza antigens have been previously associ...
Immunosenescence is believed to be responsible for poor vaccine efficacy in the elderly. To overcome...
Background: Current influenza vaccines have reduced immunogenicity and are of uncertain efficacy in ...
Parenteral immunization of BALB/c mice at 3 months of age with inactivated influenza virus vaccine e...
The ability to resist infection and respond to vaccination is severly compromised in the elderly owi...
<div><p>Current yearly influenza virus vaccines induce strain-specific neutralizing antibody (NAb) r...
Several studies have shown a reduced efficacy of influenza vaccines in the elderly compared to young...
Age affects the immune response to vaccination, with individuals at the extremes of age responding p...
BackgroundThe elderly are at high risk from influenza, in part because immunity wanes with age and t...
Influenza viruses cause severe illnesses and death, mainly in the aged population. Protection afford...
The immunogenicity and protective efficacy of a DNA vaccine encoding the circumsporozoite protein of...
Elderly people are at high risk for influenza-related morbidity and mortality due to progressive imm...
BackgroundThe elderly are at high risk from influenza, in part because immunity wanes with age and t...
Influenza causes serious and sometimes fatal disease in individuals at risk due to advanced age or i...
Several studies have shown a reduced efficacy of influenza vaccines in the elderly compared to young...
Background: T-cell responses against highly conserved influenza antigens have been previously associ...
Immunosenescence is believed to be responsible for poor vaccine efficacy in the elderly. To overcome...
Background: Current influenza vaccines have reduced immunogenicity and are of uncertain efficacy in ...
Parenteral immunization of BALB/c mice at 3 months of age with inactivated influenza virus vaccine e...