The Effect of Platelet-Rich Fibrin and Titanium Prepared Platelet-Rich Fibrin on Early Soft Tissue Healing of Extraction Sites

Objective: Physiological changes start after tooth extraction. Some post-operative symptoms may accompany this healing period, and affect patient's life quality. Many techniques have been developed to promote healing soft and hard tissue and improve patient's life quality. So, the aim of this study was to compare the early soft tissue healing of extraction sites treated with leucocyte-platelet rich fibrin (L-PRF), titanium prepared platelet rich fibrin (T-PRF) and non-treated control sites. Material&Methods:A total of 42 single root teeth were enrolled to study. Extraction site was treated by L-PRF or T-PRF. Spontanous healing sockets were considered as control sites. Landy Wound Healing Index (LWH) scores and H2O2 bubbling test results for complete wound epithelization (CWE) were recorded at 1st and 2nd week. Also, the patient was requested to record the VAS scale and the number of analgesics that taken during two days after extraction. Results: The LWH were statistically significantly improved for all groups at 2nd week according to 1st week (p<0.05). However there was no difference among three groups in each week. According to H2O2 bubbling test results, the CWE ratio at 1st week was 7.1%, 53,3% and 69.2% of control, L-PRF and T-PRF groups, respectively. The control group rate of CWE was statistically significantly lower than both of the test groups (p<0.05). Both of the test groups at 2nd week showed 100% CWE, however this rate was only 35.7% of control group. The VAS score, at 1st day, was statistically significantly higher at control group than both of the test groups at first day (p<0.05). There was non-significant difference among groups at 2nd day. There wass also non-significant difference among groups with regard to number of analgesics. Conclusion: Both T-PRF and L-PRF, which are completely autologous biomaterials, enhance wound epithelzation and reduced post-op discomfort at extraction sockets