The influence of two different techniques on the particle size and zeta potential of poly(D,L-lactide-co-glycolide) nanoparticles

The objective of this study was to analyze different formulation and process parameters and its influence on poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles size and zeta potential prepared by two different methods: spontaneous emulsification solvent diffusion (m-SESD) and solvent displacement (SD). Nanoparticles showed a size range between 200-300 nm for both methods. The freeze-drying process increased the nanoparticles size for a range of 300-500 nm. The presence of an emulsifier further increased nanoparticles stabilization. On the other hand, the nanoparticles size was dependent upon the type of drug used (ibuprofen or azelaic acid). The production yield obtained was 96.0% for nanoparticles produced with poloxamer 188 and 94.0% for nanoparticles produced with sodium laurylsulfate. As a result, it is a very promising formulation in which the m-SESD method was more effective for the analyzed parameters