Diabetes aggravates myocardial ischemia-reperfusion (I/R) injury because of the combination effects of changes in glucose and lipid energy metabolism, oxidative stress, and systemic inflammatory response. Studies have indicated that myocardial I/R may coincide and interact with sepsis and inflammation. However, the role of LPS in hypoxia/reoxygenation (H/R) injury in cardiomyocytes under high glucose conditions is still unclear. Our objective was to examine whether lipopolysaccharide (LPS) could aggravate high glucose- (HG-) and hypoxia/reoxygenation- (H/R-) induced injury by upregulating ROS production to activate NLRP3 inflammasome-mediated pyroptosis in H9C2 cardiomyocytes. H9C2 cardiomyocytes were exposed to HG (30 mM) condition with or...
Loss of pancreatic beta cells is a feature of type-2 diabetes. High glucose concentrations induce en...
Background/Aims: This study aimed to investigate whether exogenous hydrogen sulfide (H2S) confered c...
[[abstract]]Metabolic syndrome is a risk factor for the development of cardiovascular diseases. Myoc...
Objective: The mechanisms by which lipopolysaccharide (LPS) pretreatment induces cardioprotection fo...
Excessive fatty acids and sugars intake is known to affect the development of cardiovascular disease...
It is now increasingly appreciated that inflammation is not limited to the control of pathogens by t...
Myocardial contractile dysfunction in sepsis is associated with the increased morbidity and mortalit...
Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is associated...
Myocardial contractile dysfunction in sepsis is associated with the increased morbidity and mortalit...
Aims:Myocardial ischaemia followed by reperfusion (IR) causes an oxidative burst resulting in cellul...
Introduction. Ischemia/Reperfusion (I/R) is a primary cause of myocardial injury after acute myocard...
The NLRP3-inflammasome complex has emerged as an important component of inflammatory processes in me...
Abstractα-Lipoic acid (LA) has been shown to improve the diabetic cardiac symptoms. However, the und...
Diabetes is associated with myocardial lipid accumulation and an increased risk of heart failure. Al...
The in vivo response to lipopolysaccharide (LPS) occurs rapidly and has profound physiological and m...
Loss of pancreatic beta cells is a feature of type-2 diabetes. High glucose concentrations induce en...
Background/Aims: This study aimed to investigate whether exogenous hydrogen sulfide (H2S) confered c...
[[abstract]]Metabolic syndrome is a risk factor for the development of cardiovascular diseases. Myoc...
Objective: The mechanisms by which lipopolysaccharide (LPS) pretreatment induces cardioprotection fo...
Excessive fatty acids and sugars intake is known to affect the development of cardiovascular disease...
It is now increasingly appreciated that inflammation is not limited to the control of pathogens by t...
Myocardial contractile dysfunction in sepsis is associated with the increased morbidity and mortalit...
Nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome is associated...
Myocardial contractile dysfunction in sepsis is associated with the increased morbidity and mortalit...
Aims:Myocardial ischaemia followed by reperfusion (IR) causes an oxidative burst resulting in cellul...
Introduction. Ischemia/Reperfusion (I/R) is a primary cause of myocardial injury after acute myocard...
The NLRP3-inflammasome complex has emerged as an important component of inflammatory processes in me...
Abstractα-Lipoic acid (LA) has been shown to improve the diabetic cardiac symptoms. However, the und...
Diabetes is associated with myocardial lipid accumulation and an increased risk of heart failure. Al...
The in vivo response to lipopolysaccharide (LPS) occurs rapidly and has profound physiological and m...
Loss of pancreatic beta cells is a feature of type-2 diabetes. High glucose concentrations induce en...
Background/Aims: This study aimed to investigate whether exogenous hydrogen sulfide (H2S) confered c...
[[abstract]]Metabolic syndrome is a risk factor for the development of cardiovascular diseases. Myoc...