C-Tb skin test to diagnose Mycobacterium tuberculosis infection in children and HIV-infected adults: A phase 3 trial.
- Henrik Aggerbeck
- Morten Ruhwald
- Søren T Hoff
- Bettine Borregaard
- Elizabeth Hellstrom
- Mookho Malahleha
- Mirna Siebert
- Mashra Gani
- Vincent Seopela
- Andreas Diacon
- Madeleine Lourens
- Peter Andersen
- Keertan Dheda
DOIAbstract
BACKGROUND:C-Tb, an ESAT-6/CFP-10-based skin test, has similar sensitivity for active TB compared to tuberculin skin test (TST) and QuantiFERON-TB-Gold-In-Tube (QFT). However, data are limited in children and HIV-infected persons. METHODS:Asymptomatic South African contacts 0.5). All 3 tests had similar positivity rates in HIV-infected participants with active TB, however, positivity rates were reduced when CD4 counts were <100 cells/μL. In participants where active TB was excluded (n = 920), C-Tb (41%), TST (43%), and QFT (44%) also had similar test-positivity rates. Among asymptomatic contacts aged below five, 32% (28/87) tested positive with C-Tb and 32% (28/87) with TST (concordance 89%). Overall, C-Tb and TST showed a similar safety pr...
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