Antibiotic susceptibility pattern of Burkholderia cepacia complex from various clinical samples in a tertiary care center: A one year prospective study

Background: The Burkholderia cepacia complex (BCC) is a diverse group of human pathogens that cause life-threatening infections in patients with indwelling devices & those requiring intensive care. The aim of this study is to determine the antibiotic susceptibility pattern of Burkholderia cepacia complex (BCC) from various clinical samples in our hospital. Material and methods: In this one year prospective study conducted in the Department of Microbiology at Krishna Institute of Medical Sciences Limited, Secunderabad; various samples received over the year were cultured. Identification and antibiotic susceptibility testing of BCC was done by using automated Vitek® 2 Compact system (BioMérieux). Results: Out of total 4900 culture positive isolates; 43 (0.9%) Burkholderia cepacia complexes were isolated. Majority isolates were from blood 18 (41.8%) followed by respiratory samples 15 (34.8%). BCC showed maximum susceptibility to ceftazidime (72.1%) and minocycline (55.8%). Maximum resistance was seen with β–lactamase inhibitor drugs (83.7%). Conclusion: BCC being a nosocomial agent with high mortality poses a real threat in critically ill patients and needs prompt treatment and infection control