Occupational and environmental exposure to cadmium is associated with the development of urothelial cancer. The metallothionein (MT) family of genes encodes proteins that sequester metal ions and modulate physiological processes, including zinc homeostasis. Little is known about the selectivity of expression of the different MT isoforms. Here, we examined the effect of cadmium exposure on MT gene and isoform expression by normal human urothelial (NHU) cell cultures. Baseline and cadmium-induced MT gene expression was characterized by next-generation sequencing and RT-PCR; protein expression was assessed by Western blotting using isoform-specific antibodies. Expression of the zinc transporter-1 (SLC30A1) gene was also assessed. NHU cells dis...
Essential and non-essential metals can affect vital cellular processes, when over-accumulated within...
The goal of this study was to determine if the expression of the metallothionein (MT)-1/2 proteins m...
More than one and a half centuries ago, adverse human health effects were reported after use of a ca...
Occupational and environmental exposure to cadmium is associated with the development of urothelial ...
Occupational and environmental exposure to cadmium is associated with the development of urothelial ...
The metallothionein (MT) superfamily consists of 11 genes whose proteins bind to and sequester metal...
Metallothionein (MT) is a group of proteins with high cadmium (Cd) affinity and with a potential rol...
International audienceMetallothioneins (MT) are low-molecular weight, cysteine-rich metal-binding pr...
The third isoform of metallothionein, MT-3 is shown to have a restricted pattern of tissue distribut...
In contrast to the single metallothionein (MT)-1 gene of the mouse, the human MT-1 gene family is co...
Enzymes of the cytochrome P450 (CYP) super-family are implicated in cadmium (Cd) -induced nephrotoxi...
Cadmium were found in the die casting factory as by product of zinc alloy that used in the manufactu...
Metallothioneins (MTs) are thought to participate in a wide variety of physiological roles, but the ...
More than one and a half centuries ago, adverse human health effects were reported after use of a ca...
Metallothionein (MT) was first discovered over 50 years ago, as a cadmiumbinding protein in the kidn...
Essential and non-essential metals can affect vital cellular processes, when over-accumulated within...
The goal of this study was to determine if the expression of the metallothionein (MT)-1/2 proteins m...
More than one and a half centuries ago, adverse human health effects were reported after use of a ca...
Occupational and environmental exposure to cadmium is associated with the development of urothelial ...
Occupational and environmental exposure to cadmium is associated with the development of urothelial ...
The metallothionein (MT) superfamily consists of 11 genes whose proteins bind to and sequester metal...
Metallothionein (MT) is a group of proteins with high cadmium (Cd) affinity and with a potential rol...
International audienceMetallothioneins (MT) are low-molecular weight, cysteine-rich metal-binding pr...
The third isoform of metallothionein, MT-3 is shown to have a restricted pattern of tissue distribut...
In contrast to the single metallothionein (MT)-1 gene of the mouse, the human MT-1 gene family is co...
Enzymes of the cytochrome P450 (CYP) super-family are implicated in cadmium (Cd) -induced nephrotoxi...
Cadmium were found in the die casting factory as by product of zinc alloy that used in the manufactu...
Metallothioneins (MTs) are thought to participate in a wide variety of physiological roles, but the ...
More than one and a half centuries ago, adverse human health effects were reported after use of a ca...
Metallothionein (MT) was first discovered over 50 years ago, as a cadmiumbinding protein in the kidn...
Essential and non-essential metals can affect vital cellular processes, when over-accumulated within...
The goal of this study was to determine if the expression of the metallothionein (MT)-1/2 proteins m...
More than one and a half centuries ago, adverse human health effects were reported after use of a ca...