Osteoarthritis knee hip quality of life questionnaire assessment in Egyptian primary knee osteoarthritis patients: Relation to clinical and radiographic parameters

Aim of the work: To evaluate health-related quality of life (HRQoL) in primary knee osteoarthritis (KOA) patients using the osteoarthritis knee hip quality of life (OAKHQoL) questionnaire and study its relation to clinical and radiographic parameters. Patients and methods: One hundred patients with primary KOA were studied. Knee radiography was evaluated using Kellgren Lawrence (K-L) score and the OAKHQoL questionnaire assessed. Results: The patients were 75 females and 25 males; F:M 3:1. Their mean age was 54.6 ± 10.4 years, disease duration 4.6 ± 2.7 years and body mass index (BMI) 28.6 ± 2.7. 17 patients were hypertensive and 26 diabetics. 84 patients presented with bilateral KOA disease, joint stiffness in 43%, knee deformities in 18% and K-L score grade 3 in 56%. Pain component was found to have the least normalized OAKHQoL questionnaire score (49.8 ± 15.4), while mental health domain scored the highest (60.1 ± 8.2). Female gender, older age, obesity, hypertension, diabetes, bilateral KOA disease and K-L grade 3 were associated with lower questionnaire domains. Regression analysis revealed that disease duration and bilateral disease were predictors for lower scores of all OAKHQoL domains, while knee joint stiffness for four domain. Hypertension, knee deformity and K-L classification were good predictors for lower scores of two subscales. Conclusion: Egyptian patients with primary KOA have relatively poor HRQoL; reflected mainly by pain component of the OAKHQoL questionnaire. Disease duration and bilaterality were predictors for lower scores of all questionnaire domains, knee stiffness for four subscales. Hypertension, knee deformity and K-L classification were good predictors for lower scores of two subscales. Keywords: Knee osteoarthritis, Health-related quality of life, OAKHQoL questionnaire, Clinical features, K-L scor