The current study aimed to investigate the role of K+ channels subtypes in relaxant effects of catechin on rat’s aortic rings. The isometric tension of the thoracic aorta was measured using ADI PowerLab Data Acquisition System. Catechin at concentrations (10-5 to 5x10-1M) produced more potent relaxant effects in phenylephrine (10-6 M) precontracted aortic smooth muscle with Log IC50’s of -1.159 mg/ml as compared to potassium chloride (60 mM) with Log IC50’s of -6.373 mg/ml . The catechin induced relaxation in aortic rings precontracted with phenylephrine was 17.464 ± 0.068 %, where as for aortic rings precontracted with potassium was only 5.574 ± 0.131%. In aortic rings preincubated with glibenclamide (10-5M) and tetraethylammonium (1...
1 Contractile responses to KCl and membrane potentials were determined in aortic rings from spontane...
The role of voltage-dependent (I(K(v))) and large conductance Ca(2+)-activated (BK(Ca)) K(+) current...
To investigate the vasorelaxant effect of total flavones from Dendranthema morifolium (Ramat.) Tzvel...
The monoterpene, α-terpinyle acetate (TA) is a constituent of essential oils present in aromatic pla...
Vascular endothelium plays a key role in the local regulation of vascular tone and vascular architec...
The present study is designed to investigate the roles of cycloxygenase (COX) and endothelial derive...
Background: Lidocaine is an approved local anesthetic and Class 1B antiarrhythmic with a number of a...
Background: An area of ongoing controversy is the role adenosine to regulate vascular tone in condui...
OBJECTIVES: Carvacrol, a monoterpene widely present in nature, is commonly used in the food industr...
We tested the hypothesis that an abnormal function of K channels in vascular smooth muscle cells pla...
The present work investigates the mechanisms involved in the vasorelaxant effect of ent-16 alpha-met...
Sodium Nitroprusside (SNP) and Adenosine (Ado) are potent drugs used in the treatment of cardiovascu...
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Stu...
AIM: Protein kinases, activated by vasodilator substances, affect vascular function by regulating la...
The current study represents the first attempt to investigate the effect of the Euscaphic acid (EA) ...
1 Contractile responses to KCl and membrane potentials were determined in aortic rings from spontane...
The role of voltage-dependent (I(K(v))) and large conductance Ca(2+)-activated (BK(Ca)) K(+) current...
To investigate the vasorelaxant effect of total flavones from Dendranthema morifolium (Ramat.) Tzvel...
The monoterpene, α-terpinyle acetate (TA) is a constituent of essential oils present in aromatic pla...
Vascular endothelium plays a key role in the local regulation of vascular tone and vascular architec...
The present study is designed to investigate the roles of cycloxygenase (COX) and endothelial derive...
Background: Lidocaine is an approved local anesthetic and Class 1B antiarrhythmic with a number of a...
Background: An area of ongoing controversy is the role adenosine to regulate vascular tone in condui...
OBJECTIVES: Carvacrol, a monoterpene widely present in nature, is commonly used in the food industr...
We tested the hypothesis that an abnormal function of K channels in vascular smooth muscle cells pla...
The present work investigates the mechanisms involved in the vasorelaxant effect of ent-16 alpha-met...
Sodium Nitroprusside (SNP) and Adenosine (Ado) are potent drugs used in the treatment of cardiovascu...
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Stu...
AIM: Protein kinases, activated by vasodilator substances, affect vascular function by regulating la...
The current study represents the first attempt to investigate the effect of the Euscaphic acid (EA) ...
1 Contractile responses to KCl and membrane potentials were determined in aortic rings from spontane...
The role of voltage-dependent (I(K(v))) and large conductance Ca(2+)-activated (BK(Ca)) K(+) current...
To investigate the vasorelaxant effect of total flavones from Dendranthema morifolium (Ramat.) Tzvel...