Diagnosis and treatment of the blepharochalasis

Blepharochalasis is a rare disease that often onsets in childhood or adolescence. It is characterized by non-painful, non-erythemaous eyelid angioedema with intermittent recurrent episodes, resulting in relaxation, atrophy and thinned of eyelid structures. The late complications, attributing to continuous underlying structural destruction, including ptosis, orbital fat prolapse, lacrimal glands prolapse and blepharophimosis etc. The pathogenesis is not clear yet, researchers have indicated that it might be associated with inheritance and endocrine factors. Nevertheless, histopathology examination showed elastic fibers breakdown, IgA deposits and inflammatory cell infiltration. Based on this, it is assumed that the immunologic mechanism and inflammatory reaction play a significant role in the development of the disease. According to the clinical stage, there are two treatment patterns: oral medicine and surgery at present