Intraoperative carcinoid syndrome during small-bowel neuroendocrine tumour surgery

Myrtille Fouché
Yves Bouffard
Mary-Charlotte Le Goff
Johanne Prothet
François Malavieille
Pierre Sagnard
Françoise Christin
Davy Hayi-Slayman
Arnaud Pasquer
Gilles Poncet
Thomas Walter
Thomas Rimmelé

Open PDF

Open link

Publication date

November 2018

DOI

10.1530/EC-18-0324

Publisher

Bioscientifica

Journal

Endocrine Connections

Abstract

Only few descriptions of intraoperative carcinoid syndrome (ioCS) have been reported. The primary objective of this study was to describe ioCS. A second aim was to identify risk factors of ioCS. We retrospectively analysed patients operated for small-bowel neuroendocrine tumour in our institution between 2007 and 2015, and receiving our preventive local regimen of octreotide continuous administration. ioCS was defined as highly probable in case of rapid (<5 min) arterial blood pressure changes ≥40%, not explained by surgical/anaesthetic management and regressive ≥20% after octreotide bolus injection. Probable cases were ioCS which did not meet all criteria of highly-probable ioCS. Suspected ioCS were detected on the anaesthesia record by an...