Prions in eukaryotes have been linked to diseases, evolutionary capacitance, large-scale genetic control and long-term memory formation. In bacteria, constructed prion-forming proteins have been described, such as the prion-forming protein recently described for Clostridium botulinum transcription terminator Rho. Here, I analyzed the evolution of the Rho prion-forming domain across bacteria, and discovered that its conservation is sporadic both in the Clostridium genus and in bacteria generally. Nonetheless, it has an apparent evolutionary reach into eight or more different bacterial phyla. Motivated by these results, I investigated whether this pattern of wide-ranging evolutionary sporadicity is typical of bacterial prion-like domains. A m...
Prion disorders are a group of fatal neurodegenerative conditions of mammals. The key molecular even...
peer reviewedBACKGROUND: Prion proteins conform a special class among amyloids due to their ability ...
Abstract. Modification of the cellular prion protein has been correlated with the acquisition of sev...
Prions in eukaryotes have been linked to diseases, evolutionary capacitance, large-scale genetic con...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2015.Cataloged from PD...
Prion proteins were initially associated with diseases such as Creutzfeldt Jakob and transmissible s...
Prions are molecules characterized by self-propagation, which can undergo a conformational switch le...
Prion-like proteins can switch between a soluble intrinsically disordered conformation and a highly ...
Our current understanding of prion biology and disease is largely based on studies performed on mamm...
In the more than 20 years since its discovery, both the phylogenetic origin and cellular function of...
In the more than twenty years since its discovery, both the phylogenetic origin and cellular functio...
In the more than twenty years since its discovery, both the phylogenetic origin and cellular functio...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2011.This electronic versi...
Background: Prions are transmissible, propagating alternative states of proteins, and are usually ma...
PriB is a primosomal protein that catalyzes DNA replication in Procaryota. The replication pathway s...
Prion disorders are a group of fatal neurodegenerative conditions of mammals. The key molecular even...
peer reviewedBACKGROUND: Prion proteins conform a special class among amyloids due to their ability ...
Abstract. Modification of the cellular prion protein has been correlated with the acquisition of sev...
Prions in eukaryotes have been linked to diseases, evolutionary capacitance, large-scale genetic con...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2015.Cataloged from PD...
Prion proteins were initially associated with diseases such as Creutzfeldt Jakob and transmissible s...
Prions are molecules characterized by self-propagation, which can undergo a conformational switch le...
Prion-like proteins can switch between a soluble intrinsically disordered conformation and a highly ...
Our current understanding of prion biology and disease is largely based on studies performed on mamm...
In the more than 20 years since its discovery, both the phylogenetic origin and cellular function of...
In the more than twenty years since its discovery, both the phylogenetic origin and cellular functio...
In the more than twenty years since its discovery, both the phylogenetic origin and cellular functio...
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2011.This electronic versi...
Background: Prions are transmissible, propagating alternative states of proteins, and are usually ma...
PriB is a primosomal protein that catalyzes DNA replication in Procaryota. The replication pathway s...
Prion disorders are a group of fatal neurodegenerative conditions of mammals. The key molecular even...
peer reviewedBACKGROUND: Prion proteins conform a special class among amyloids due to their ability ...
Abstract. Modification of the cellular prion protein has been correlated with the acquisition of sev...