Abstract We propose a model of dynamical noncommutative quantum mechanics in which the noncommutative strengths, describing the properties of the commutation relations of the coordinate and momenta, respectively, are arbitrary energy-dependent functions. The Schrödinger equation in the energy-dependent noncommutative algebra is derived for a two-dimensional system for an arbitrary potential. The resulting equation reduces in the small energy limit to the standard quantum mechanical one, while for large energies the effects of the noncommutativity become important. We investigate in detail three cases, in which the noncommutative strengths are determined by an independent energy scale, related to the vacuum quantum fluctuations, by the parti...