The Möbius strip spacetime topology and the entangled antipodal points on black hole surfaces, recently described by ‘t Hooft, display an unnoticed relationship with the Borsuk-Ulam theorem from algebraic topology. Considering this observation and other recent claims which suggest that quantum entanglement takes place on the antipodal points of a S3 hypersphere, a novel topological framework can be developed: a feature encompassed in an S2 unentangled state gives rise, when projected one dimension higher, to two entangled particles. This allows us to achieve a mathematical description of the holographic principle occurring in S2. Furthermore, our observations let us to hypothesize that a) quantum entanglement might occur in a four-dimens...