Molecular Analysis of Fluoroquinolone-resistant Salmonella Paratyphi A Isolate, India
- Satheesh Nair
- Madhulika Unnikrishnan
- Keith Turner
- Subash Chandra Parija
- Carol Churcher
- John Wain
- Belgode Narasimha Harish
Publication date
March 2006
DOI Publisher
Centers for Disease Control and Prevention (CDC) Journal
Emerging Infectious DiseasesAbstract
Salmonella enterica serovar Paratyphi A is increasingly a cause of enteric fever. Sequence analysis of an Indian isolate showed a unique strain with high-level resistance to ciprofloxacin associated with double mutations in the DNA gyrase subunit gyrA (Ser83→Phe and Asp87→Gly) and a mutation in topoisomerase IV subunit parC (Ser80→Arg)
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