Increasing Incidence of Zygomycosis (Mucormycosis), France, 1997–2006
- Dounia Bitar
- Dieter Van Cauteren
- Fanny Lanternier
- Eric Dannaoui
- Didier Che
- Francoise Dromer
- Jean-Claude Desenclos
- Olivier Lortholary
DOIAbstract
We analyzed hospital records to provide a population-based estimate of zygomycosis incidence and trends over a 10-year period at a national level in France. Data showed an increasing incidence from 0.7/million in 1997 to 1.2/million in 2006 (p<0.001). We compared our data with those from the French Mycosis Study Group, a recently established voluntary network of French mycologists coordinated by the National Reference Center for Mycoses and Antifungals. We documented that incidence of zygomycosis increased, particularly in patients with hematologic malignancies or bone marrow transplants. The role of previous exposure to antifungal drugs lacking activity against zygomycetes could explain this increase but does not appear exclusive. Incidenc...
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