Molecular Evolution of Respiratory Syncytial Virus Fusion Gene, Canada, 2006–2010
- Jesse Papenburg
- Julie Carbonneau
- Marie-Ève Hamelin
- Sandra Isabel
- Xavier Bouhy
- Najwa Ohoumanne
- Pierre Déry
- Bosco A. Paes
- Jacques Corbeil
- Michel G. Bergeron
- Gaston De Serres
- Guy Boivin
Publication date
January 2012
DOI Publisher
Centers for Disease Control and Prevention (CDC) Journal
Emerging Infectious DiseasesAbstract
To assess molecular evolution of the respiratory syncytial virus (RSV) fusion gene, we analyzed RSV-positive specimens from 123 children in Canada who did or did not receive RSV immunoprophylaxis (palivizumab) during 2006–2010. Resistance-conferring mutations within the palivizumab binding site occurred in 8.7% of palivizumab recipients and none of the nonrecipients
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