Pneumocystis jirovecii Pneumonia in Patients with or without AIDS, France
- Antoine Roux
- Emmanuel Canet
- Sandrine Valade
- Florence Gangneux-Robert
- Samia Hamane
- Ariane Lafabrie
- Daniéle Maubon
- Anne Debourgogne
- Soléne Le Gal
- Fréderic Dalle
- Marion Leterrier
- Dominique Toubas
- Christelle Pomares
- Anne Pauline Bellanger
- Julie Bonhomme
- Antoine Berry
- Isabelle Durand-Joly
- Denis Magne
- Denis Pons
- Christophe Hennequin
- Eric Maury
- Patricia Roux
- Élie Azoulay
DOIAbstract
Pneumocystis jirovecii pneumonia (PCP) in patients without AIDS is increasingly common. We conducted a prospective cohort study of consecutive patients with proven PCP; of 544 patients, 223 (41%) had AIDS (AIDS patients) and 321 (59%) had other immunosuppressive disorders (non-AIDS patients). Fewer AIDS than non-AIDS patients required intensive care or ventilation, and the rate of hospital deaths—17.4% overall—was significantly lower for AIDS versus non-AIDS patients (4% vs. 27%; p<0.0001). Multivariable analysis showed the odds of hospital death increased with older age, receipt of allogeneic bone marrow transplant, immediate use of oxygen, need for mechanical ventilation, and longer time to treatment; HIV-positive status or receipt of a s...
Add to ORKG