pncA Gene Mutations Associated with Pyrazinamide Resistance in Drug-Resistant Tuberculosis, South Africa and Georgia
- Salim Allana
- Elena Shashkina
- Barun Mathema
- Nino Bablishvili
- Nestani Tukvadze
- N. Sarita Shah
- Russell R. Kempker
- Henry M. Blumberg
- Pravi Moodley
- Koleka Mlisana
- James C.M. Brust
- Neel R. Gandhi
Publication date
March 2017
DOI Publisher
Centers for Disease Control and Prevention (CDC) Journal
Emerging Infectious DiseasesAbstract
Although pyrazinamide is commonly used for tuberculosis treatment, drug-susceptibility testing is not routinely available. We found polymorphisms in the pncA gene for 70% of multidrug-resistant and 96% of extensively drug-resistant Mycobacterium tuberculosis isolates from South Africa and Georgia. Assessment of pyrazinamide susceptibility may be prudent before using it in regimens for drug-resistant tuberculosis
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