High-Level Fosfomycin Resistance in Vancomycin-Resistant Enterococcus faecium
- Yan Guo
- Adam D. Tomich
- Christi L. McElheny
- Vaughn S. Cooper
- Amelia Tait-Kamradt
- Min Chen
- Fupin Hu
- Louis B. Rice
- Nicolas Sluis-Cremer
- Yohei Doi
Publication date
November 2017
DOI Publisher
Centers for Disease Control and Prevention (CDC) Journal
Emerging Infectious DiseasesAbstract
Of 890 vancomycin-resistant Enterococcus faecium isolates obtained by rectal screening from patients in Pittsburgh, Pennsylvania, USA, 4 had MICs >1,024 μg/mL for fosfomycin. These isolates had a Cys119Asp substitution in the active site of UDP-N-acetylglucosamine enolpyruvyl transferase. This substitution increased the fosfomycin MIC >4-fold and rendered this drug inactive in biochemical assays
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