Acute and Delayed Deaths after West Nile Virus Infection, Texas, USA, 2002–2012

  • David C.E. Philpott
  • Melissa S. Nolan
  • Nicole Evert
  • Bonny Mayes
  • Dawn Hesalroad
  • Eric Fonken
  • Kristy O. Murray
Publication date
February 2019
Publisher
Centers for Disease Control and Prevention (CDC)
ISSN
1080-6040
Journal
Emerging Infectious Diseases

Abstract

Infection with West Nile virus (WNV) has a well-characterized acute disease process. However, long-term consequences are less understood. We searched death records for 4,142 residents of Texas, USA, infected with WNV during 2002–2012 and identified 557 (13%) deaths. We analyzed all-cause and cause-specific deaths after WNV infection by calculating standardized mortality ratios and using statewide mortality data. Acute-phase deaths (90 days after symptom onset) occurred in 268 (7%) of the remaining 3,853 case-patients; 210 (78%) of these deaths occurred in patients with WNND. Convalescent-phase WNND case-patients showed excess deaths from infectious and renal causes; case-patients <60 years of age had increased risk for all-cause death, spec...

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