Whole-Genome Sequencing of Drug-Resistant Mycobacterium tuberculosis Strains, Tunisia, 2012–2016
- Imen Bouzouita
- Andrea Maurizio Cabibbe
- Alberto Trovato
- Henda Daroui
- Asma Ghariani
- Basma Midouni
- Leila Essalah
- Emna Mehiri
- Daniela Maria Cirillo
- Leila Slim Saidi
Publication date
March 2019
DOI Publisher
Centers for Disease Control and Prevention (CDC) Journal
Emerging Infectious DiseasesAbstract
To investigate transmission of drug-resistant strains of Mycobacterium tuberculosis in Tunisia, we performed whole-genome sequencing on 46 multidrug-resistant strains isolated during 2012–2016. Core-genome multilocus sequence typing grouped 30 strains (65.2%) into 3 clusters, indicating extensive recent transmission and Haarlem clone predominance. Whole-genome sequencing might help public health services undertake appropriate control actions
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