A scoring strategy for progression risk and rates of treatment completion in subjects with latent tuberculosis.

Michael Scolarici
Ken Dekitani
Ling Chen
Marcia Sokol-Anderson
Daniel F Hoft
Soumya Chatterjee

Open link

Publication date

January 2018

DOI

10.1371/journal.pone.0207582

Publisher

Public Library of Science (PLoS)

Journal

PLoS ONE

Abstract

It is unknown whether patients with LTBI at high vs. low risk of developing active TB are currently adequately identified and treated in the US. In this study our objective was 1) To retrospectively apply the online calculator (tstin3d.com) to determine the probability of having LTBI and assign cumulative risk of progression. 2) Measure treatment outcomes in subjects with Low: 0-<10%, Intermediate: 10-<50% and High: 50-100% cumulative risk. We performed medical record review of tuberculin skin test and/or Interferon-γ release assay (IGRAs) positive patients with LTBI seen from 2010-2015. Of 125 subjects included, 51(41%), 46 (37%) and 28 (22%) subjects were in Low, Intermediate and High risk groups respectively. Tstin3d.com was useful in de...