Micronuclei Comparison in Lichen Planus and Oral Lichenoid Responses

BACKGROUND AND OBJECTIVE: Lichen planus is a mucocutaneous chronic inflammatory disease with unknown etiology. Malignant potential of oral lichen planus (OLP) and lichenoid reactions (OLR) are controversial. Since micronucleus frequency of cells is representative of risk of malignancy, the aim of present study was to evaluate micronucleus frequency in these lesions. METHODS: In this cross-sectional study, study group consisted of 20 OLP and 20 OLR which clinically and histopathologically had been confirmed and 20 healthy individuals without oral lesions and systemic disease who presented in oral medicine department of Babol dental college. After receiving written consent, smears were prepared from lesion site at buccal mucosa by cytobrush and were stained at laboratory using Papanicolaou stain. In each slide 500 cells were assessed under light microscope at 400X magnification; mean number of micronucleated cells and mean total numbers of micronuclei were calculated. FINDINGS: Mean number of micronucleated cells in OLP, OLR and normal mucosa were 5.20±3.73, 5.65±3.66 and 0.95±1.19 and number of micronuclei were 6.75±4.94, 8±4.66 and 1.30±1.72 respectively. Mean number of micronucleated cells and number of micronuclei were significantly greater in OLP and OLR than normal mucosa (p