Abstract Background The aim of this study was to characterize the influence of cardiopulmonary bypass (CPB) on myocardial remodeling in newborns and children. Methods Biopsies from the right atrium were taken before and after CPB from 4 newborns (5–11 days old) and 7 children (8 months–16 years old). Immunostainings on 10 µm heart tissue frozen sections were performed to detect c-kit+ cells, leukocytes (CD45+ cells), Ki67+ cycling cells. The percentage of 8-hydroxy-guanosine (8-dOHG)+cardiomyocytes and non-cardiomyocytes [(8-dOHG)+-index] were determined to quantify oxidative stress. Results Δ c-kit+CD45− cells (resident cardiac stem cells) were increased in newborns (2.2 ± 1.9/mm2) and decreased in children − 1.5 ± 0.7/mm2, p < 0.01. The (...
AbstractIntroduction: The vulnerability of pediatric myocardium to ischemia is poorly documented in ...
INTRODUCTION: Reducing cardiopulmonary bypass (CPB) induced inflammatory injury is a potentially imp...
Despite advances in surgical techniques and medical management, congenital heart defects still have ...
ObjectiveSingle-ventricle patients undergoing pediatric heart surgery are a high-risk group owing to...
Additional file 1. (1) Information letter to patients and parents, (2) consent form for anonymous pu...
AbstractObjective: Neonates undergoing cardiac surgery have a systemic inflammatory reaction with re...
ObjectivesThis study investigates the effects of controlled reoxygenation cardiopulmonary bypass on ...
Background: Infants and small children who undergo cardiac surgery due to congenital heart disorders...
OBJECTIVE: Neonates undergoing cardiac surgery have a systemic inflammatory reaction with release of...
To determine the effect of operations with cardiopulmonary bypass on the immunologic function of pol...
Cardiopulmonary bypass (CPB) is used increasingly to correct cyanotic heart defects during early inf...
Various pathological factors accompanying any cardiac surgery can cause intraoperative systemic infla...
Congenital heart disease (CHD) is the most common birth defect, causing an important rate of morbidi...
Objective: Cardiopulmonary bypass is associated with ischemia-reperfusion injury to multiple organs....
Cardiopulmonary bypass (CPB) leads to a generalized inflammatory reaction, resulting in increased po...
AbstractIntroduction: The vulnerability of pediatric myocardium to ischemia is poorly documented in ...
INTRODUCTION: Reducing cardiopulmonary bypass (CPB) induced inflammatory injury is a potentially imp...
Despite advances in surgical techniques and medical management, congenital heart defects still have ...
ObjectiveSingle-ventricle patients undergoing pediatric heart surgery are a high-risk group owing to...
Additional file 1. (1) Information letter to patients and parents, (2) consent form for anonymous pu...
AbstractObjective: Neonates undergoing cardiac surgery have a systemic inflammatory reaction with re...
ObjectivesThis study investigates the effects of controlled reoxygenation cardiopulmonary bypass on ...
Background: Infants and small children who undergo cardiac surgery due to congenital heart disorders...
OBJECTIVE: Neonates undergoing cardiac surgery have a systemic inflammatory reaction with release of...
To determine the effect of operations with cardiopulmonary bypass on the immunologic function of pol...
Cardiopulmonary bypass (CPB) is used increasingly to correct cyanotic heart defects during early inf...
Various pathological factors accompanying any cardiac surgery can cause intraoperative systemic infla...
Congenital heart disease (CHD) is the most common birth defect, causing an important rate of morbidi...
Objective: Cardiopulmonary bypass is associated with ischemia-reperfusion injury to multiple organs....
Cardiopulmonary bypass (CPB) leads to a generalized inflammatory reaction, resulting in increased po...
AbstractIntroduction: The vulnerability of pediatric myocardium to ischemia is poorly documented in ...
INTRODUCTION: Reducing cardiopulmonary bypass (CPB) induced inflammatory injury is a potentially imp...
Despite advances in surgical techniques and medical management, congenital heart defects still have ...