Investigations on the anti-diabetic potential of novel marine seaweed Sargassum longiotom against alloxan-induced diabetes mellitus: A pilot study

The present study evaluated the hypoglycemic effect of brown algae Sargassum longiotom in alloxan-induced diabetic rats. After the treatment with S. longiotom extract, there is a significant reduction (p<0.001) in blood glucose when compared with the diabetic control group. Moreover the ethanolic extract of S. longiotom significantly reduces (p<0.001) the levels of triglycerides, low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol dose dependent manner. Alternatively, it increases the high-density lipoprotein cholesterol level in the treated groups. The values of SGOT, SGPT and ALP have been significantly reduced (p