PURPOSE: Investigate the extended release behaviour of compacts containing mixtures of hydrophilic HPMC and PEO in hydrating media of differing ionic strengths. METHODS: The extended release behaviour of various HPMC:PEO compacts was investigated using dissolution testing, confocal microscopy and magnetic resonance imaging, with respect to polymer ratio and ionic strength of the hydrating media. RESULTS: Increasing HPMC content gave longer extended release times, but a greater sensitivity to high ionic dissolution environments. Increasing PEO content reduced this sensitivity. The addition of PEO to a predominantly HPMC matrix reduced release rate sensitivity to high ionic environments. Confocal microscopy of early gel layer development show...
The use of controlled release formulations in the pharmaceutical industry offers several advantages...
A variety of imaging techniques are currently used within the field of pharmaceutics to help underst...
The evaluation of the effects of different media ionic strengths and pH on the release of hydrochlor...
Purpose Investigate the extended release behaviour of compacts containing mixtures of hydrophilic...
Extensive studies of extended release tablets based on hydrophilic polymers have illuminated several...
The purpose of this study was to investigate the hydration behavior of two matrix formulations conta...
Four different HPMC batches were characterized to investigate properties related to crit. functional...
The aim of the present investigation was to understand the swelling behaviour of HPMC and PEO-based ...
Hydrophilic matrix tablets are a compressed well mixed composite of drug substance and excipients in...
Hydrophylic matrix tablets containing polyethylene oxides as the retarding polymer has been succesfu...
Purpose: So far, the hydrated part of the HPMC matrix has commonly been denoted as a "gel" or "pseud...
Extended release oral drug delivery (ER) offers many therapeutic benefits. Hydroxypropyl methylcellu...
The purpose of this study was to gain further understanding of how the substituent heterogeneity of ...
A real-time confocal fluorescence imaging method has been developed which allows the critical early ...
Purpose. The dissolution of HPMC matrix tablets containing different amounts of highly soluble(manni...
The use of controlled release formulations in the pharmaceutical industry offers several advantages...
A variety of imaging techniques are currently used within the field of pharmaceutics to help underst...
The evaluation of the effects of different media ionic strengths and pH on the release of hydrochlor...
Purpose Investigate the extended release behaviour of compacts containing mixtures of hydrophilic...
Extensive studies of extended release tablets based on hydrophilic polymers have illuminated several...
The purpose of this study was to investigate the hydration behavior of two matrix formulations conta...
Four different HPMC batches were characterized to investigate properties related to crit. functional...
The aim of the present investigation was to understand the swelling behaviour of HPMC and PEO-based ...
Hydrophilic matrix tablets are a compressed well mixed composite of drug substance and excipients in...
Hydrophylic matrix tablets containing polyethylene oxides as the retarding polymer has been succesfu...
Purpose: So far, the hydrated part of the HPMC matrix has commonly been denoted as a "gel" or "pseud...
Extended release oral drug delivery (ER) offers many therapeutic benefits. Hydroxypropyl methylcellu...
The purpose of this study was to gain further understanding of how the substituent heterogeneity of ...
A real-time confocal fluorescence imaging method has been developed which allows the critical early ...
Purpose. The dissolution of HPMC matrix tablets containing different amounts of highly soluble(manni...
The use of controlled release formulations in the pharmaceutical industry offers several advantages...
A variety of imaging techniques are currently used within the field of pharmaceutics to help underst...
The evaluation of the effects of different media ionic strengths and pH on the release of hydrochlor...