A large body of evidence that has accumulated over the past decade strongly supports the role of both blood–brain barrier (BBB) dysfunction and perivascular inflammation in the pathophysiology of epilepsy. Recent preclinical studies indicate that prolonged seizure- or brain injury-induced BBB dysfunction and subsequent perivascular inflammation may play an important role in post-traumatic epileptogenesis. In turn, perivascular inflammation can further sustain BBB dysfunction. In genetic epilepsies, such as tuberous sclerosis complex and other related epileptogenic developmental pathologies, there is an association between the underlying gene mutation, BBB dysfunction, and perivascular inflammation, but evidence for a causal link to epilepsy...
Recent studies have shown that neurologic inflammation may both precipitate and sustain seizures, su...
Brain damage due to stroke or traumatic brain injury (TBI), both leading causes of serious long-term...
Epilepsy, one of the most common neurological disorders, affects between 0.5 and 2 percent of the po...
The blood-brain barrier (BBB) is important to maintain brain homeostasis, which is crucial for the f...
Over the last 15 years, attention has been focused on dysfunction of the cerebral vasculature and in...
BACKGROUND: Epilepsy is a common and debilitating consequence of traumatic brain injury (TBI). Seizu...
Perturbations of neurovascular integrity and breakdown of the blood-brain barrier may lead to neuron...
Pericytes are a component of the blood–brain barrier (BBB) neurovascular unit, in which they play a ...
BACKGROUND: Traumatic brain injury (TBI) causes 10-20% of acquired epilepsy, which typically develop...
The most common forms of acquired epilepsies arise following acute brain insults such as traumatic b...
Abstract Epilepsy, a neurological disease characterized by recurrent seizures, is often associated w...
Background: Blood brain barrier (BBB) permeability plays an important role in the brain impairments....
Epilepsy is the third most common chronic brain disorder, and is characterized by an enduring predis...
During the last decade, experimental research has demonstrated a prominent role of glial cells, acti...
Copyright © 2011 Itai Weissberg et al. This is an open access article distributed under the Creative...
Recent studies have shown that neurologic inflammation may both precipitate and sustain seizures, su...
Brain damage due to stroke or traumatic brain injury (TBI), both leading causes of serious long-term...
Epilepsy, one of the most common neurological disorders, affects between 0.5 and 2 percent of the po...
The blood-brain barrier (BBB) is important to maintain brain homeostasis, which is crucial for the f...
Over the last 15 years, attention has been focused on dysfunction of the cerebral vasculature and in...
BACKGROUND: Epilepsy is a common and debilitating consequence of traumatic brain injury (TBI). Seizu...
Perturbations of neurovascular integrity and breakdown of the blood-brain barrier may lead to neuron...
Pericytes are a component of the blood–brain barrier (BBB) neurovascular unit, in which they play a ...
BACKGROUND: Traumatic brain injury (TBI) causes 10-20% of acquired epilepsy, which typically develop...
The most common forms of acquired epilepsies arise following acute brain insults such as traumatic b...
Abstract Epilepsy, a neurological disease characterized by recurrent seizures, is often associated w...
Background: Blood brain barrier (BBB) permeability plays an important role in the brain impairments....
Epilepsy is the third most common chronic brain disorder, and is characterized by an enduring predis...
During the last decade, experimental research has demonstrated a prominent role of glial cells, acti...
Copyright © 2011 Itai Weissberg et al. This is an open access article distributed under the Creative...
Recent studies have shown that neurologic inflammation may both precipitate and sustain seizures, su...
Brain damage due to stroke or traumatic brain injury (TBI), both leading causes of serious long-term...
Epilepsy, one of the most common neurological disorders, affects between 0.5 and 2 percent of the po...