Chronic inflammation and metabolic reprogramming have been proposed as hallmarks of cancer development. Currently, many of the functional clues between these two phenomena are studied under the integrative view of functional stroma-epithelia interaction. It has been proposed that stromal cells, due to their abundance and avidity for glucose, are able to modify the metabolic behavior of an entire solid tumor. In the present study, using a mammary stromal cell line derived from healthy tissue subjected to long-term culture in low (5 mM) or high (25 mM) glucose, we found that the hyperglycemic condition favors the establishment of a pro-inflammatory and pro-oxidant environment characterized by the induction of the COX-2/PGE2 axis. In this cond...
Due to poor tumour-associated vasculature, tumour cells are subjected to a fluctuating microenvironm...
Metabolic alterations in cancer cells are primarily caused by oncogenic mutations and cancer cells a...
Metabolic changes that facilitate tumor growth are one of the hallmarks of cancer. The triggers of t...
Adiposity and diabetes affect breast cancer (BC) progression. We addressed whether glucose may affec...
Breast tumors belong to the type of desmoplastic lesion in which a stiffer tissue structure is a det...
SummaryThe tumor microenvironment plays a critical role in cancer progression, but the precise mecha...
SummaryFailure of T cells to protect against cancer is thought to result from lack of antigen recogn...
The tumor microenvironment plays a critical role in cancer progression, but the precise mechanisms b...
Interactions occurring between malignant cells and stromal microenvi-ronment greatly influence progr...
In breast tumor, interactions occurring between malignant cells and stromal mi-croenvironment heavil...
Fibroblast-like stromal cells modulate cancer cells through secreted factors and adhesion, but those...
<div><p>Fibroblast-like stromal cells modulate cancer cells through secreted factors and adhesion, b...
BACKGROUND: Mesenchymal stem/stromal cells (MSCs) from the decidua basalis (DBMSCs) of the human pla...
Glucose transport and consumption are increased in tumors, and this is considered a diagnostic index...
Diabetes mellitus (DM) and pancreatic cancer are intimately related, as approximately 85% of patient...
Due to poor tumour-associated vasculature, tumour cells are subjected to a fluctuating microenvironm...
Metabolic alterations in cancer cells are primarily caused by oncogenic mutations and cancer cells a...
Metabolic changes that facilitate tumor growth are one of the hallmarks of cancer. The triggers of t...
Adiposity and diabetes affect breast cancer (BC) progression. We addressed whether glucose may affec...
Breast tumors belong to the type of desmoplastic lesion in which a stiffer tissue structure is a det...
SummaryThe tumor microenvironment plays a critical role in cancer progression, but the precise mecha...
SummaryFailure of T cells to protect against cancer is thought to result from lack of antigen recogn...
The tumor microenvironment plays a critical role in cancer progression, but the precise mechanisms b...
Interactions occurring between malignant cells and stromal microenvi-ronment greatly influence progr...
In breast tumor, interactions occurring between malignant cells and stromal mi-croenvironment heavil...
Fibroblast-like stromal cells modulate cancer cells through secreted factors and adhesion, but those...
<div><p>Fibroblast-like stromal cells modulate cancer cells through secreted factors and adhesion, b...
BACKGROUND: Mesenchymal stem/stromal cells (MSCs) from the decidua basalis (DBMSCs) of the human pla...
Glucose transport and consumption are increased in tumors, and this is considered a diagnostic index...
Diabetes mellitus (DM) and pancreatic cancer are intimately related, as approximately 85% of patient...
Due to poor tumour-associated vasculature, tumour cells are subjected to a fluctuating microenvironm...
Metabolic alterations in cancer cells are primarily caused by oncogenic mutations and cancer cells a...
Metabolic changes that facilitate tumor growth are one of the hallmarks of cancer. The triggers of t...