Introduction: BDSM (bondage and discipline, dominance and submission, and sadism and masochism) increasingly receives attention from the scientific community. Where earlier research efforts mainly focused on epidemiologic characteristics, psychological and biologic factors driving BDSM preferences have recently gained interest as well. Aim: To bring together all the existing scientific literature on BDSM from a biopsychosocial perspective. Methods: Based on the PRISMA guidelines, the current systematic review brings together all the existing literature on BDSM from a biopsychosocial perspective. Main Outcome Measure: Prevalence rates of BDSM interests were investigated in the literature, as well as the associations between BDSM interests on...