RESULTS OF THE STUDY OF THYROID HORMONE, PARATHYROID AND CORTISOL IN GIRLS WITH EPILEPSY ADOLESCENCE

Abstract: the purpose of this work was to improve the diagnostic methods of hormonal disorders in girls with epilepsy adolescence by examining indicators of thyroid, parathyroid glands, cortisol and identify their differences with the data corresponding to the level of hormones in the blood of a comparison group of girls. Material and methods. The study included 50 girls with epilepsy, aged from 8 to 17 years for girls and 47 comparison group of the same age. For all children, determined the blood levels of parathyroid hormone, triiodothyronine, thyroxine, thyrotropin, thyroglobulin antibodies and cortisol in accordance with instructions for use reagent for ELISA (Enzyme-linked immunosorbent assay) determination of hormones in human serum, approved by the Ministry of Health of the Russian Federation. The results of the study. Girls 8-17 years with epilepsy blood levels of parathyroid hormone, triiodothyronine, thyroxine, TSH and thyroglobulin antibodies were not significantly different. Significantly different blood levels of cortisol in girls 8-13 and 14-17. In girls, the comparison group blood levels of parathyroid hormone triiodothyronine and significantly different for children 8-13 and 14-17 years, for thyroxine – children 8-9 and 10-17 years, for cortisol – children 8-11 and 12-17 years. The blood levels of a comparison group of girls 8-17 years of TSH (thyroid stimulating hormone) and thyroglobulin antibodies were not significantly different. Cortisol levels in the blood of girls with epilepsy younger and older age groups was significantly higher than that of the comparison group of girls in these age groups, the level of parathyroid hormone T3 and – significantly higher than that of girls 14-17 years of comparison, the level of thyroid stimulating hormone, antibodies to thyroglobulin and T4 – significantly higher than the comparison group of girls aged 8-17. Conclusions. Revealed changes in hormone levels in the blood of girls with epilepsy compared with a comparison group based on age and investigated their reliability