Characteristic of renal response to the salt-loading test in patients with decompensated liver cirrhosis

Edema-ascitic syndrome is one of the clinical manifestations of decompensation of liver cirrhosis (LC) in the development of which an essential role belongs to renal dysfunction with disturbance of water-electrolyte metabolism. The purpose of our study was to study the function of the kidneys in conditions of spontaneous diuresis and during the salt load in this category of patients. 21 patients with a low-active decompensated LC of toxic etiology at the age of 32 to 68 years and 18 practically healthy people were examined. The functional state of the kidneys was assessed by the clearance method under conditions of a 12-hour spontaneous night and 2-hour induced diuresis (using 0.5% sodium chloride solution at a rate of 5 ml / kg body weight). Impaired renal function in spontaneous diuresis was manifested by a slight increase in the concentration of blood creatinine (