New insecticides are needed for control of disease-vectoring mosquitoes and this research evaluates the activity of new carbamate acetylcholinesterase (AChE) inhibitors. Biochemical and toxicological characterization of carbamates based on the parent structure of terbam, 3-tert-butylphenyl methylcarbamate, was performed. In vitro enzyme inhibition selectivity (Anopheles gambiae versus human) was assessed by the Ellman assay, as well as the lethality to whole insects by the World Health Organization (WHO) paper contact assay. Bromination at the phenyl C6 position increased inhibitory potency to both AChEs, whereas a 6-iodo substituent led to loss of potency, and both halogenations caused a significant reduction of mosquitocidal activity. Sim...
Aedes aegypti L. is the primary vector of dengue and yellow fever viruses, and use of aerosolized in...
Mosquitoes of the Anopheles (An.) and Aedes (Ae.) genus are principal vectors of human diseases incl...
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology S...
Acetylcholinesterase (AChE) is a proven target for control of the malaria mosquito (Anopheles gambia...
Widespread pyrethroid resistance has caused an urgent need to develop new insecticides for control o...
Acetylcholinesterase (AChE) is an essential enzyme with an evolutionary conserved function: to termi...
<div><p>Acetylcholinesterase (AChE) is a proven target for control of the malaria mosquito (<em>Anop...
Insecticide resistance jeopardizes the prevention of infectious diseases such as malaria and dengue ...
Diseases such as malaria and dengue impose great economic burdens and are a serious threat to public...
Resistance development in insects significantly threatens the important benefits obtained by insecti...
International audienceResistance to insecticides has become a critical issue in pest management and ...
Resistance to insecticides has become a critical issue in pest management and it is particularly chr...
Mosquitoes of the Anopheles (An.) and Aedes (Ae.) genus are principal vectors of human diseases incl...
Mosquitoes of the Anopheles (An.) and Aedes (Ae.) genus are principal vectors of human diseases incl...
<div><p>Mosquitoes of the <i>Anopheles (An</i>.<i>)</i> and <i>Aedes (Ae</i>.<i>)</i> genus are prin...
Aedes aegypti L. is the primary vector of dengue and yellow fever viruses, and use of aerosolized in...
Mosquitoes of the Anopheles (An.) and Aedes (Ae.) genus are principal vectors of human diseases incl...
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology S...
Acetylcholinesterase (AChE) is a proven target for control of the malaria mosquito (Anopheles gambia...
Widespread pyrethroid resistance has caused an urgent need to develop new insecticides for control o...
Acetylcholinesterase (AChE) is an essential enzyme with an evolutionary conserved function: to termi...
<div><p>Acetylcholinesterase (AChE) is a proven target for control of the malaria mosquito (<em>Anop...
Insecticide resistance jeopardizes the prevention of infectious diseases such as malaria and dengue ...
Diseases such as malaria and dengue impose great economic burdens and are a serious threat to public...
Resistance development in insects significantly threatens the important benefits obtained by insecti...
International audienceResistance to insecticides has become a critical issue in pest management and ...
Resistance to insecticides has become a critical issue in pest management and it is particularly chr...
Mosquitoes of the Anopheles (An.) and Aedes (Ae.) genus are principal vectors of human diseases incl...
Mosquitoes of the Anopheles (An.) and Aedes (Ae.) genus are principal vectors of human diseases incl...
<div><p>Mosquitoes of the <i>Anopheles (An</i>.<i>)</i> and <i>Aedes (Ae</i>.<i>)</i> genus are prin...
Aedes aegypti L. is the primary vector of dengue and yellow fever viruses, and use of aerosolized in...
Mosquitoes of the Anopheles (An.) and Aedes (Ae.) genus are principal vectors of human diseases incl...
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology S...