Gliomas are the most frequent primary tumors of central nervous system and represent a heterogeneous group of tumors that originates from the glial cells. TP53, PTEN, and CDKN2A are important tumor suppressor genes that encode proteins involved in sustaining cellular homeostasis by different signaling pathways. Though genetic alterations in these genes play a significant role in tumorigenesis, few studies are available regarding the incidence and relation of concomitant TP53, PTEN, and CDKN2A alterations in gliomas. The purpose of this study was to evaluate the occurrence of mutation and deletion in these genes, through single-strand conformational polymorphism, array-comparative genomic hybridization, and fluorescence in situ hybridization...
The MMAC/PTEN tumor suppressor gene has an essential biological role in the formation of glioblastom...
SummaryMutations in the PTEN, TP53, and RB1 pathways are obligate events in the pathogenesis of huma...
The histological subclassification of gliomas is increasingly assisted by the underlying molecular g...
This research was funded partially by Fundação de Amparo à Pesquisa do Estado do Pará (FAPESPA, Bel...
In this study we established the simultaneous status of TP53, p16, p14ARF and PTEN tumor suppressor ...
Lower-grade (World Health Organization Grades II and III) gliomas vary widely in clinical behavior a...
p53, p16 and PTEN are the most commonly altered tumor suppressor genes in human cancers. In the pres...
The relationship between MMAC/PTEN, DMBT1 and the progression and prognosis of glioma, and the assoc...
De novo glioblastomas develop in older patients without prior clinical history of less malignant tum...
Gliosarcomas are morphologically heterogeneous tumors of the central nervous system composed of glio...
Frequent loss of heterozygosity (LOH) and mutations of the tumor suppressor gene PTEN (phosphatase a...
The present study determined mutations of phosphatase and tensin homolog (PTEN) gene in patients suf...
Ten glioma cell lines were examined for alterations of the p16, p15 and p53 genes, which were tumor ...
Object. Several genes have been shown to carry mutations in human malignant gliomas, including the p...
P16 and P14ARF are two tumor suppressors encoded by the locus ink4a-arf which is frequently deleted ...
The MMAC/PTEN tumor suppressor gene has an essential biological role in the formation of glioblastom...
SummaryMutations in the PTEN, TP53, and RB1 pathways are obligate events in the pathogenesis of huma...
The histological subclassification of gliomas is increasingly assisted by the underlying molecular g...
This research was funded partially by Fundação de Amparo à Pesquisa do Estado do Pará (FAPESPA, Bel...
In this study we established the simultaneous status of TP53, p16, p14ARF and PTEN tumor suppressor ...
Lower-grade (World Health Organization Grades II and III) gliomas vary widely in clinical behavior a...
p53, p16 and PTEN are the most commonly altered tumor suppressor genes in human cancers. In the pres...
The relationship between MMAC/PTEN, DMBT1 and the progression and prognosis of glioma, and the assoc...
De novo glioblastomas develop in older patients without prior clinical history of less malignant tum...
Gliosarcomas are morphologically heterogeneous tumors of the central nervous system composed of glio...
Frequent loss of heterozygosity (LOH) and mutations of the tumor suppressor gene PTEN (phosphatase a...
The present study determined mutations of phosphatase and tensin homolog (PTEN) gene in patients suf...
Ten glioma cell lines were examined for alterations of the p16, p15 and p53 genes, which were tumor ...
Object. Several genes have been shown to carry mutations in human malignant gliomas, including the p...
P16 and P14ARF are two tumor suppressors encoded by the locus ink4a-arf which is frequently deleted ...
The MMAC/PTEN tumor suppressor gene has an essential biological role in the formation of glioblastom...
SummaryMutations in the PTEN, TP53, and RB1 pathways are obligate events in the pathogenesis of huma...
The histological subclassification of gliomas is increasingly assisted by the underlying molecular g...