Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury : A Randomized Clinical Trial

Biodistribution and translational pharmacokinetic modeling of a human recombinant alkaline phosphatase

Peters, E.
Stevens, J.
Arend, J.
Guan, Z.
Raaben, W.
Laverman, P.
Elsas, A. van
Masereeuw, R.
Pickkers, P.

January 2015

Contains fulltext : 154642.pdf (publisher's version ) (Closed access)Clinical tria...

Alkaline phosphatase: a possible treatment for sepsis-associated acute kidney injury in critically ill patients

Peters, E.
Heemskerk, S.
Masereeuw, R.
Pickkers, P.

January 2014

Item does not contain fulltextAcute kidney injury (AKI) is a common disease in the intensive care un...

Pharmacokinetic Modeling and Dose Selection in a Randomized, Double-Blind, Placebo-Controlled Trial of a Human Recombinant Alkaline Phosphatase in Healthy Volunteers

Peters, E.
Heuberger, J.A.
Tiessen, R.
Elsas, A. van
Masereeuw, R.
Arend, J.
Stevens, J.
Pickkers, P.

January 2016

Contains fulltext : 171174.pdf (publisher's version ) (Open Access)BACKGROUND AND ...

Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury: A Randomized Clinical Trial.

Pickkers, Peter
Mehta, Ravindra L
Murray, Patrick T
Joannidis, Michael
Molitoris, Bruce A
Kellum, John A
Bachler, Mirjam
Hoste, Eric A J
Hoiting, Oscar
Krell, Kenneth
Ostermann, Marlies
Rozendaal, Wim
Valkonen, Miia
Brealey, David
Beishuizen, Albertus
Meziani, Ferhat
Murugan, Raghavan
de Geus, Hilde
Payen, Didier
van den Berg, Erik
Arend, Jacques
STOP-AKI Investigators
Dive, Alain-Michel

January 2018

Sepsis-associated acute kidney injury (AKI) adversely affects long-term kidney outcomes and survival...

Effect of human recombinant alkaline phosphatase on 7-day creatinine clearance in patients with sepsis-associated acute kidney injury : a randomized clinical trial

Pickkers, Peter
Mehta, Ravindra L
Murray, Patrick T
Joannidis, Michael
Molitoris, Bruce A
Kellum, John A
Bachler, Mirjam
Hoste, Eric
Hoiting, Oscar
Krell, Kenneth
Ostermann, Marlies
Rozendaal, Wim
Valkonen, Miia
Brealey, David
Beishuizen, Albertus
Meziani, Ferhat
Murugan, Raghavan
de Geus, Hilde
Payen, Didier
van den Berg, Erik
Arend, Jacques

January 2018

IMPORTANCE: Sepsis-associated acute kidney injury (AKI) adversely affects long-term kidney outcomes ...

Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury. A Randomized Clinical Trial

Peter Pickkers, MD
Ravindra L. Mehta
Patrick T. Murray
stop aki investigators
Rocco m

January 2018

Importance: Sepsis-associated acute kidney injury (AKI) adversely affects long-term kidney outcomes ...

Study protocol for a multicentre randomised controlled trial: Safety, Tolerability, efficacy and quality of life Of a human recombinant alkaline Phosphatase in patients with sepsis-associated Acute Kidney Injury (STOP-AKI)

Peters, E.
Mehta, R.L.
Murray, P.T.
Hummel, J.
Joannidis, M.
Kellum, J.A.
Arend, J.
Pickkers, P.

January 2016

Contains fulltext : 171555.pdf (publisher's version ) (Open Access)INTRODUCTION: A...

Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: a prospective randomized double-blind placebo-controlled trial.

Pickkers, P.
Heemskerk, S.
Schouten, J.A.
Laterre, P.F.
Vincent, J.L.
Beishuizen, A.
Jorens, P.G.
Spapen, H.
Bulitta, M.
Peters, W.H.M.
Hoeven, J.G. van der

January 2012

Contains fulltext : 108970.pdf (publisher's version ) (Open Access)INTRODUCTION: T...

Effects of a human recombinant alkaline phosphatase on renal hemodynamics, oxygenation and inflammation in two models of acute kidney injury

Peters, E.
Ergin, B.
Kandil, A.
Gurel-Gurevin, E.
Elsas, A. van
Masereeuw, R.
Pickkers, P.
Ince, C.

January 2016

Contains fulltext : 172437.pdf (publisher's version ) (Closed access)Two small cli...

Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: A prospective randomized double-blind placebo-controlled trial

Pickkers, Peter
Heemskerk, Suzanne
Schouten, Jeroen
Laterre, Pierre-François
Vincent, Jean-Louis
Beishuizen, Albertus
Jorens, Philippe G.
Spapen, Herbert
Bulitta, Michael
Peters, Wilbert H.M.
van der Hoeven, Johannes G.

January 2012

Introduction: To evaluate whether alkaline phosphatase (AP) treatment improves renal function in sep...

Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate

Peters, E.
Geraci, S.
Heemskerk, S.
Wilmer, M.J.
Bilos, A.
Kraenzlin, B.
Gretz, N.
Pickkers, P.
Masereeuw, R.

January 2015

Contains fulltext : 152594.pdf (publisher's version ) (Closed access)BACKGROUND AN...

Human recombinant alkaline phosphatase inhibits ex vivo platelet activation in humans

Tunjungputri, R.N.
Peters, E.
Ven, A. van der
Groot, P.G. de
Mast, Q. de
Pickkers, P.

January 2016

Contains fulltext : 172714.pdf (publisher's version ) (Closed access)Sepsis-associ...

Alkaline phosphatase to treat septic acute kidney injury

Peters, E.

January 2017

Contains fulltext : 169251.pdf (publisher's version ) (Open Access)Radboud Univers...

The potential of alkaline phosphatase as a treatment for sepsis-associated acute kidney injury

Peters, Esther
Masereeuw, R.
Pickkers, Peter

January 2014

Sepsis-associated acute kidney injury (AKI) is associated with a high attributable mortality and an ...

Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL)

Pickkers, Peter
Angus, Derek C
Bass, Kristie
Bellomo, Rinaldo
van den Berg, Erik
Bernholz, Juliane
Bestle, Morten H
Doi, Kent
Doig, Chistopher J
Ferrer, Ricard
Francois, Bruno
Gammelager, Henrik
Pedersen, Ulf Goettrup
Hoste, Eric
Iversen, Susanne
Joannidis, Michael
Kellum, John A
Liu, Kathleen
Meersch, Melanie
Mehta, Ravindra
Millington, Scott
Murray, Patrick T
Nichol, Alistair
Ostermann, Marlies
Pettilä, Ville
Solling, Christoffer
Winkel, Matthias
Young, Paul J
Zarbock, Alexander
Carter, Angus
Fries, Dietmar
Eller, Philip
Gérard, Ludovic
DeSchryver, Nicolas
Diltoer, Elisabeth
Huberlant, Vincent
Michaux, Isabelle
Honore, Patrick
Fivez, Tom
Doig, Christopher
Wood, Gordon
Boyd, John
Turgeon, Alexis
Kamper, Maj
Strøm, Thomas
Iversen, Sussanne
Gammelager, Hendrik
Rasmussen, Bodil Steen
Sølling, Christoffer Grant
Mæller, Morten Hyllander
Groefte, Thorbjoern
Dey, Nilanjan
Pedersen, Ulf Gøttrup
Valkonen, Mila
Uusalo, Panu
Jalkanen, Ville
Meziani, Ferhat
Lemarie, Jermie
Plantefeve, Gaetan
Bachoumas, Konstantimos
Dufour, Jean Louis
Fedou, Anne-Laure
Asfar, Pierre
Monnet, Xavier
Vinsonneau, Christophe
Gibot, Sebastien
Guitton, Christophe
Quenot, Jean-Pierre
Muller, Gregoire
Lefrant, Jean Yves
Mercier, Emmanuelle
Mebazaa, Alexandre
Kortgen, Andreas
Fichtner, Sebastian
Kluge, Stefan
Marx, Gernot
Martin-Loeches, Ignatio
McNicolas, Bairbre
Kamohara, Hidenobu
Harada, Masahiro
Nakagami, Takuo
Adachi, Shingo
Ota, Kohei
Furuya, Ryo
Tsuruoka, Ayumu
Mizushima, Yasuaki
Inoue, Satoki
Tuinman, Pieter
Wim Roozendaal, F
Beishuizen, Bert
Hoiting, Oscar
Dormans, Tom
Van Zanten, Arthur
Young, Paul
Williams, Anthony
McArthur, Colin
Twardowski, Pawel
McGuinness, Shay
Roca, Ricard Ferrer
Cardenas, Carol Lorencio
Perez, Anna Navas
Sagasti, Fernando Martinez
Welters, Ingeborg
Wise, Matt
Waddy, Sam
MacCallum, Niall
Murugan, Raghaven
Gomez, Hernando
Busse, Larry
Boldt, David
Bernard, Andrew
Files, Daniel
Margolis, Benjamin
Mosier, Jarrod
Truwit, Jonathon
Zamora, Felix
Davison, Danielle
Exline, Matthew
Nielsen, Nathan
Hite, Duncan

January 2024

PURPOSE: Ilofotase alfa is a human recombinant alkaline phosphatase with reno-protective effects tha...

Biodistribution and translational pharmacokinetic modeling of a human recombinant alkaline phosphatase

Peters, E.
Stevens, J.
Arend, J.
Guan, Z.
Raaben, W.
Laverman, P.
Elsas, A. van
Masereeuw, R.
Pickkers, P.

January 2015

Contains fulltext : 154642.pdf (publisher's version ) (Closed access)Clinical tria...

Alkaline phosphatase: a possible treatment for sepsis-associated acute kidney injury in critically ill patients

Peters, E.
Heemskerk, S.
Masereeuw, R.
Pickkers, P.

January 2014

Item does not contain fulltextAcute kidney injury (AKI) is a common disease in the intensive care un...

Pharmacokinetic Modeling and Dose Selection in a Randomized, Double-Blind, Placebo-Controlled Trial of a Human Recombinant Alkaline Phosphatase in Healthy Volunteers

Peters, E.
Heuberger, J.A.
Tiessen, R.
Elsas, A. van
Masereeuw, R.
Arend, J.
Stevens, J.
Pickkers, P.

January 2016

Contains fulltext : 171174.pdf (publisher's version ) (Open Access)BACKGROUND AND ...

Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury: A Randomized Clinical Trial.

Pickkers, Peter
Mehta, Ravindra L
Murray, Patrick T
Joannidis, Michael
Molitoris, Bruce A
Kellum, John A
Bachler, Mirjam
Hoste, Eric A J
Hoiting, Oscar
Krell, Kenneth
Ostermann, Marlies
Rozendaal, Wim
Valkonen, Miia
Brealey, David
Beishuizen, Albertus
Meziani, Ferhat
Murugan, Raghavan
de Geus, Hilde
Payen, Didier
van den Berg, Erik
Arend, Jacques
STOP-AKI Investigators
Dive, Alain-Michel

January 2018

Sepsis-associated acute kidney injury (AKI) adversely affects long-term kidney outcomes and survival...

Effect of human recombinant alkaline phosphatase on 7-day creatinine clearance in patients with sepsis-associated acute kidney injury : a randomized clinical trial

Pickkers, Peter
Mehta, Ravindra L
Murray, Patrick T
Joannidis, Michael
Molitoris, Bruce A
Kellum, John A
Bachler, Mirjam
Hoste, Eric
Hoiting, Oscar
Krell, Kenneth
Ostermann, Marlies
Rozendaal, Wim
Valkonen, Miia
Brealey, David
Beishuizen, Albertus
Meziani, Ferhat
Murugan, Raghavan
de Geus, Hilde
Payen, Didier
van den Berg, Erik
Arend, Jacques

January 2018

IMPORTANCE: Sepsis-associated acute kidney injury (AKI) adversely affects long-term kidney outcomes ...

Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury. A Randomized Clinical Trial

Peter Pickkers, MD
Ravindra L. Mehta
Patrick T. Murray
stop aki investigators
Rocco m

January 2018

Importance: Sepsis-associated acute kidney injury (AKI) adversely affects long-term kidney outcomes ...

Study protocol for a multicentre randomised controlled trial: Safety, Tolerability, efficacy and quality of life Of a human recombinant alkaline Phosphatase in patients with sepsis-associated Acute Kidney Injury (STOP-AKI)

Peters, E.
Mehta, R.L.
Murray, P.T.
Hummel, J.
Joannidis, M.
Kellum, J.A.
Arend, J.
Pickkers, P.

January 2016

Contains fulltext : 171555.pdf (publisher's version ) (Open Access)INTRODUCTION: A...

Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: a prospective randomized double-blind placebo-controlled trial.

Pickkers, P.
Heemskerk, S.
Schouten, J.A.
Laterre, P.F.
Vincent, J.L.
Beishuizen, A.
Jorens, P.G.
Spapen, H.
Bulitta, M.
Peters, W.H.M.
Hoeven, J.G. van der

January 2012

Contains fulltext : 108970.pdf (publisher's version ) (Open Access)INTRODUCTION: T...

Effects of a human recombinant alkaline phosphatase on renal hemodynamics, oxygenation and inflammation in two models of acute kidney injury

Peters, E.
Ergin, B.
Kandil, A.
Gurel-Gurevin, E.
Elsas, A. van
Masereeuw, R.
Pickkers, P.
Ince, C.

January 2016

Contains fulltext : 172437.pdf (publisher's version ) (Closed access)Two small cli...

Alkaline phosphatase for treatment of sepsis-induced acute kidney injury: A prospective randomized double-blind placebo-controlled trial

Pickkers, Peter
Heemskerk, Suzanne
Schouten, Jeroen
Laterre, Pierre-François
Vincent, Jean-Louis
Beishuizen, Albertus
Jorens, Philippe G.
Spapen, Herbert
Bulitta, Michael
Peters, Wilbert H.M.
van der Hoeven, Johannes G.

January 2012

Introduction: To evaluate whether alkaline phosphatase (AP) treatment improves renal function in sep...

Alkaline phosphatase protects against renal inflammation through dephosphorylation of lipopolysaccharide and adenosine triphosphate

Peters, E.
Geraci, S.
Heemskerk, S.
Wilmer, M.J.
Bilos, A.
Kraenzlin, B.
Gretz, N.
Pickkers, P.
Masereeuw, R.

January 2015

Contains fulltext : 152594.pdf (publisher's version ) (Closed access)BACKGROUND AN...

Human recombinant alkaline phosphatase inhibits ex vivo platelet activation in humans

Tunjungputri, R.N.
Peters, E.
Ven, A. van der
Groot, P.G. de
Mast, Q. de
Pickkers, P.

January 2016

Contains fulltext : 172714.pdf (publisher's version ) (Closed access)Sepsis-associ...

Alkaline phosphatase to treat septic acute kidney injury

Peters, E.

January 2017

Contains fulltext : 169251.pdf (publisher's version ) (Open Access)Radboud Univers...

The potential of alkaline phosphatase as a treatment for sepsis-associated acute kidney injury

Peters, Esther
Masereeuw, R.
Pickkers, Peter

January 2014

Sepsis-associated acute kidney injury (AKI) is associated with a high attributable mortality and an ...

Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL)

Pickkers, Peter
Angus, Derek C
Bass, Kristie
Bellomo, Rinaldo
van den Berg, Erik
Bernholz, Juliane
Bestle, Morten H
Doi, Kent
Doig, Chistopher J
Ferrer, Ricard
Francois, Bruno
Gammelager, Henrik
Pedersen, Ulf Goettrup
Hoste, Eric
Iversen, Susanne
Joannidis, Michael
Kellum, John A
Liu, Kathleen
Meersch, Melanie
Mehta, Ravindra
Millington, Scott
Murray, Patrick T
Nichol, Alistair
Ostermann, Marlies
Pettilä, Ville
Solling, Christoffer
Winkel, Matthias
Young, Paul J
Zarbock, Alexander
Carter, Angus
Fries, Dietmar
Eller, Philip
Gérard, Ludovic
DeSchryver, Nicolas
Diltoer, Elisabeth
Huberlant, Vincent
Michaux, Isabelle
Honore, Patrick
Fivez, Tom
Doig, Christopher
Wood, Gordon
Boyd, John
Turgeon, Alexis
Kamper, Maj
Strøm, Thomas
Iversen, Sussanne
Gammelager, Hendrik
Rasmussen, Bodil Steen
Sølling, Christoffer Grant
Mæller, Morten Hyllander
Groefte, Thorbjoern
Dey, Nilanjan
Pedersen, Ulf Gøttrup
Valkonen, Mila
Uusalo, Panu
Jalkanen, Ville
Meziani, Ferhat
Lemarie, Jermie
Plantefeve, Gaetan
Bachoumas, Konstantimos
Dufour, Jean Louis
Fedou, Anne-Laure
Asfar, Pierre
Monnet, Xavier
Vinsonneau, Christophe
Gibot, Sebastien
Guitton, Christophe
Quenot, Jean-Pierre
Muller, Gregoire
Lefrant, Jean Yves
Mercier, Emmanuelle
Mebazaa, Alexandre
Kortgen, Andreas
Fichtner, Sebastian
Kluge, Stefan
Marx, Gernot
Martin-Loeches, Ignatio
McNicolas, Bairbre
Kamohara, Hidenobu
Harada, Masahiro
Nakagami, Takuo
Adachi, Shingo
Ota, Kohei
Furuya, Ryo
Tsuruoka, Ayumu
Mizushima, Yasuaki
Inoue, Satoki
Tuinman, Pieter
Wim Roozendaal, F
Beishuizen, Bert
Hoiting, Oscar
Dormans, Tom
Van Zanten, Arthur
Young, Paul
Williams, Anthony
McArthur, Colin
Twardowski, Pawel
McGuinness, Shay
Roca, Ricard Ferrer
Cardenas, Carol Lorencio
Perez, Anna Navas
Sagasti, Fernando Martinez
Welters, Ingeborg
Wise, Matt
Waddy, Sam
MacCallum, Niall
Murugan, Raghaven
Gomez, Hernando
Busse, Larry
Boldt, David
Bernard, Andrew
Files, Daniel
Margolis, Benjamin
Mosier, Jarrod
Truwit, Jonathon
Zamora, Felix
Davison, Danielle
Exline, Matthew
Nielsen, Nathan
Hite, Duncan

January 2024

PURPOSE: Ilofotase alfa is a human recombinant alkaline phosphatase with reno-protective effects tha...

Biodistribution and translational pharmacokinetic modeling of a human recombinant alkaline phosphatase

Peters, E.
Stevens, J.
Arend, J.
Guan, Z.
Raaben, W.
Laverman, P.
Elsas, A. van
Masereeuw, R.
Pickkers, P.

January 2015

Contains fulltext : 154642.pdf (publisher's version ) (Closed access)Clinical tria...

Alkaline phosphatase: a possible treatment for sepsis-associated acute kidney injury in critically ill patients

Peters, E.
Heemskerk, S.
Masereeuw, R.
Pickkers, P.

January 2014

Item does not contain fulltextAcute kidney injury (AKI) is a common disease in the intensive care un...

Pharmacokinetic Modeling and Dose Selection in a Randomized, Double-Blind, Placebo-Controlled Trial of a Human Recombinant Alkaline Phosphatase in Healthy Volunteers

Peters, E.
Heuberger, J.A.
Tiessen, R.
Elsas, A. van
Masereeuw, R.
Arend, J.
Stevens, J.
Pickkers, P.

January 2016

Contains fulltext : 171174.pdf (publisher's version ) (Open Access)BACKGROUND AND ...

Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury : A Randomized Clinical Trial

Abstract

Extracted data

Topics

Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury : A Randomized Clinical Trial

Abstract

Extracted data

Topics

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