Because of the failure of immunotherapy as single agent in a number of cancers, current clinical trials are focusing on combining immunotherapy with other therapies. The most frequently chosen combination for immunotherapy is chemotherapy. However, almost no preclinical data on this combination is available. Some studies even showed a dismal effect of combining chemotherapy with immunotherapy. Taken into account that each of the therapies chosen in a combination will influence the cancer cells but also immune effector cells as well as immunosuppressive cells, and that these three partners will also interact with each other, launching a combination to the patient without proper immune monitoring and preclinical evidence might be devastating
Abstract Although recent FDA approvals on ipilimumab and sipuleucel-T represent major milestones, th...
Advances in our understanding of the complex mechanisms of immune regulation and the interactions be...
Although cancer chemotherapy has historically been con-sidered immune suppressive, it is now accepte...
Because of the failure of immunotherapy as single agent in a number of cancers, current clinical tri...
Because of the failure of immunotherapy as single agent in a number of cancers, current clinical tri...
Not until the turn of this century has immunotherapy become a fundamental component of cancer treatm...
Abstract The results of recent clinical trials have demon-strated that cancer vaccines continue to s...
Harnessing the immune system to treat cancer through inhibitors of CTLA4 and PD-L1 has revolutionize...
Targeted therapies have induced high response rates and improved survival in patients with cancer. H...
Although cancer chemotherapy has historically been considered immune suppressive, it is now accepted...
Immunotherapy has substantial attention in oncology due to the success of CTLA-4 and PD-1 inhibitors...
Clinical responses to immunotherapy can be complete and sustained; however, compared to responses t...
Cancer immunotherapy and in particular monoclonal antibodies blocking the inhibitory programed cell ...
The clinical efficacy of most therapeutic vaccines against cancer has not yet met its promise. Data ...
Although recent FDA approvals on ipilimumab and sipuleucel-T represent major milestones, the ultimat...
Abstract Although recent FDA approvals on ipilimumab and sipuleucel-T represent major milestones, th...
Advances in our understanding of the complex mechanisms of immune regulation and the interactions be...
Although cancer chemotherapy has historically been con-sidered immune suppressive, it is now accepte...
Because of the failure of immunotherapy as single agent in a number of cancers, current clinical tri...
Because of the failure of immunotherapy as single agent in a number of cancers, current clinical tri...
Not until the turn of this century has immunotherapy become a fundamental component of cancer treatm...
Abstract The results of recent clinical trials have demon-strated that cancer vaccines continue to s...
Harnessing the immune system to treat cancer through inhibitors of CTLA4 and PD-L1 has revolutionize...
Targeted therapies have induced high response rates and improved survival in patients with cancer. H...
Although cancer chemotherapy has historically been considered immune suppressive, it is now accepted...
Immunotherapy has substantial attention in oncology due to the success of CTLA-4 and PD-1 inhibitors...
Clinical responses to immunotherapy can be complete and sustained; however, compared to responses t...
Cancer immunotherapy and in particular monoclonal antibodies blocking the inhibitory programed cell ...
The clinical efficacy of most therapeutic vaccines against cancer has not yet met its promise. Data ...
Although recent FDA approvals on ipilimumab and sipuleucel-T represent major milestones, the ultimat...
Abstract Although recent FDA approvals on ipilimumab and sipuleucel-T represent major milestones, th...
Advances in our understanding of the complex mechanisms of immune regulation and the interactions be...
Although cancer chemotherapy has historically been con-sidered immune suppressive, it is now accepte...
Add to ORKG