MOESM1 of Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease

MOESM1 of Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of hemozoin in Suppressing Hsp70 and NF-ÎşB Activation

Prakasha Kempaiah (336992)
Karol Dokladny (695594)
Zachary Karim (3937778)
Evans Raballah (3937781)
John Ongâecha (4590142)
Pope Moseley (5816735)
Douglas Perkins (18857)

October 2018

Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of Hemozoin in Suppressing Hsp7...

Purified and Recombinant Hemopexin: Protease Activity and Effect on Neutrophil Chemotaxis

Tian Lin
Jialin Liu
Feng Huang
Tjitske S R van Engelen
Sujatha R Thundivalappil
Frank E Riley
Michael Super
Alexander L Watters
Ann Smith
Nathan Brinkman
Donald E Ingber
H Shaw Warren

January 2016

Abstract Infusion of the heme-binding protein hemopexin has been proposed as a novel approach to dec...

MOESM1 of Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway

Xiaobo Gao (5998001)
Shun Guo (3606506)
Song Zhang (180477)
An Liu (291211)
Lei Shi (8144)
Yan Zhang (8098)

November 2018

Additional file 1: Figure S1. The body weight of HFD mice at 0th, 4th, 8th, and 12th. Figure S2. The...

Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease

Gregory M Vercellotti
Ping Zhang
Julia Nguyen
Fuad Abdulla
Chunsheng Chen
Phong Nguyen
Carlos Nowotny
Clifford J Steer
Ann Smith
John D Belcher

July 2016

Abstract Sickle cell disease (SCD) patients have low serum hemopexin (Hpx) levels due to chronic hem...

Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction.

John D Belcher
Chunsheng Chen
Julia Nguyen
Fuad Abdulla
Ping Zhang
Hao Nguyen
Phong Nguyen
Trevor Killeen
Sylvia M Miescher
Nathan Brinkman
Karl A Nath
Clifford J Steer
Gregory M Vercellotti

During hemolysis, hemoglobin and heme released from red blood cells promote oxidative stress, inflam...

Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction

John D. Belcher (190588)
Chunsheng Chen (694570)
Julia Nguyen (694571)
Fuad Abdulla (694572)
Ping Zhang (86495)
Hao Nguyen (5142821)
Phong Nguyen (694573)
Trevor Killeen (5142830)
Sylvia M. Miescher (413148)
Nathan Brinkman (5142824)
Karl A. Nath (5142827)
Clifford J. Steer (137110)
Gregory M. Vercellotti (190593)

April 2018

<div><p>During hemolysis, hemoglobin and heme released from red blood cells promote oxidative stress...

Plasma-Derived Hemopexin as a Candidate Therapeutic Agent for Acute Vaso-Occlusion in Sickle Cell Disease: Preclinical Evidence

Thomas Gentinetta
John D. Belcher
Valérie Brügger-Verdon
Jacqueline Adam
Tanja Ruthsatz
Joseph Bain
Daniel Schu
Lisa Ventrici
Monika Edler
Hadi Lioe
Kalpeshkumar Patel
Chunsheng Chen
Julia Nguyen
Fuad Abdulla
Ping Zhang
Andreas Wassmer
Meena Jain
Marcel Mischnik
Matthias Pelzing
Kirstee Martin
Roslyn Davis
Svetlana Didichenko
Alexander Schaub
Nathan Brinkman
Eva Herzog
Adrian Zürcher
Gregory M. Vercellotti
Gregory J. Kato
Gerald Höbarth

January 2022

People living with sickle cell disease (SCD) face intermittent acute pain episodes due to vaso-occlu...

Critical Role of Hemopexin Mediated Cytoprotection in the Pathophysiology of Sickle Cell Disease

Rani Ashouri
Madison Fangman
Alicia Burris
Miriam O. Ezenwa
Diana J. Wilkie
Sylvain Doré

June 2021

Circulating hemopexin is the primary protein responsible for the clearance of heme; therefore, it is...

ApoE-/- Mice Lacking Hemopexin Develop Increased Atherosclerosis via Mechanisms That Include Oxidative Stress and Altered Macrophage Function

Thosani, Niyati Mehta

January 2015

Objective: We previously reported that Hemopexin (Hx), an acute phase protein and a heme scavenger, ...

Identification of Hemopexin as an Anti-Inflammatory Factor That Inhibits Synergy of Hemoglobin with HMGB1 in Sterile and Infectious Inflammation

Lin, Tian
Sammy, Fatima
Yang, Huan
Thundivalappil, Sujatha
Hellman, Judith
Tracey, Kevin J
Warren, H Shaw

August 2012

Hemoglobin is released from lysed RBCs in numerous clinical settings. High mobility group box 1 (HMG...

Hemopexin dosing improves cardiopulmonary dysfunction in murine sickle cell disease

Buehler, Paul W
Swindle, Delaney
Pak, David I
Ferguson, Scott k
Majka, Susan M
Karoor, Vijaya
Moldovan, Radu
Sintas, Chantal
Black, Jennifer
Gentinetta, Thomas
Buzzi, Raphael M
Vallelian, Florence
Wassmer, Andreas
Edler, Monika
Bain, Joseph
Schu, Daniel
Hassell, Kathryn
Nuss, Rachelle
Schaer, Dominik J
Irwin, David C

November 2021

Hemopexin (Hpx) is a crucial defense protein against heme liberated from degraded hemoglobin during ...

Role of hemoglobin/heme scavenger protein hemopexin in atherosclerosis and inflammatory diseases

Mehta, Niyati U
Reddy, Srinivasa T

October 2015

Purpose of reviewHemoglobin and its scavenger proteins haptoglobin and hemopexin (Hx) associate with...

Hemopexin in severe inflammation and infection: mouse models and human diseases

Lin, Tian
Maita, Dayana
Thundivalappil, Sujatha R
Riley, Frank E
Hambsch, Jasmin
Van Marter, Linda J
Christou, Helen A
Berra, Lorenzo
Fagan, Shawn
Christiani, David C
Warren, H Shaw

June 2015

Introduction: Cell-free plasma hemoglobin is associated with poor outcome in patients with sepsis. E...

MOESM1 of Annexin A5 Increases Survival in Murine Sepsis Model by Inhibiting HMGB1-Mediated Proinflammation and Coagulation

Jung Park (2351599)
Jong-Hwa Jang (5817146)
Eun Choi (3455003)
Young Kim (4006)
Eun Lee (418436)
In Jung (3414695)
Hee Han (1966600)
T-C Wu (119729)
Chien-Fu Hung (61506)
Tae Kang (3620276)
Yeong-Min Park (171090)

October 2018

Annexin A5 Increases Survival in Murine Sepsis Model by Inhibiting HMGB1-Mediated Proinflammation an...

Inhibition of Neutrophil Migration by Hemopexin Leads to Increased Mortality Due to Sepsis in Mice

SPILLER, Fernando
COSTA, Carlotta
SOUTO, Fabricio O.
VINCHI, Francesca
MESTRINER, Fabiola L. A. C.
LAURE, Helen J.
ALVES-FILHO, Jose C.
FREITAS, Andressa
ROSA, Jose C.
FERREIRA, Sergio H.
ALTRUDA, Fiorella
HIRSCH, Emilio
GREENE, Lewis J.
TOLOSANO, Emanuela
CUNHA, Fernando Q.

January 2011

Rationale: The reduction of neutrophil migration to the bacterial focus is associated with poor outc...

MOESM1 of Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of hemozoin in Suppressing Hsp70 and NF-ÎşB Activation

Prakasha Kempaiah (336992)
Karol Dokladny (695594)
Zachary Karim (3937778)
Evans Raballah (3937781)
John Ongâecha (4590142)
Pope Moseley (5816735)
Douglas Perkins (18857)

October 2018

Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of Hemozoin in Suppressing Hsp7...

Purified and Recombinant Hemopexin: Protease Activity and Effect on Neutrophil Chemotaxis

Tian Lin
Jialin Liu
Feng Huang
Tjitske S R van Engelen
Sujatha R Thundivalappil
Frank E Riley
Michael Super
Alexander L Watters
Ann Smith
Nathan Brinkman
Donald E Ingber
H Shaw Warren

January 2016

Abstract Infusion of the heme-binding protein hemopexin has been proposed as a novel approach to dec...

MOESM1 of Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway

Xiaobo Gao (5998001)
Shun Guo (3606506)
Song Zhang (180477)
An Liu (291211)
Lei Shi (8144)
Yan Zhang (8098)

November 2018

Additional file 1: Figure S1. The body weight of HFD mice at 0th, 4th, 8th, and 12th. Figure S2. The...

Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease

Gregory M Vercellotti
Ping Zhang
Julia Nguyen
Fuad Abdulla
Chunsheng Chen
Phong Nguyen
Carlos Nowotny
Clifford J Steer
Ann Smith
John D Belcher

July 2016

Abstract Sickle cell disease (SCD) patients have low serum hemopexin (Hpx) levels due to chronic hem...

Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction.

John D Belcher
Chunsheng Chen
Julia Nguyen
Fuad Abdulla
Ping Zhang
Hao Nguyen
Phong Nguyen
Trevor Killeen
Sylvia M Miescher
Nathan Brinkman
Karl A Nath
Clifford J Steer
Gregory M Vercellotti

During hemolysis, hemoglobin and heme released from red blood cells promote oxidative stress, inflam...

Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction

John D. Belcher (190588)
Chunsheng Chen (694570)
Julia Nguyen (694571)
Fuad Abdulla (694572)
Ping Zhang (86495)
Hao Nguyen (5142821)
Phong Nguyen (694573)
Trevor Killeen (5142830)
Sylvia M. Miescher (413148)
Nathan Brinkman (5142824)
Karl A. Nath (5142827)
Clifford J. Steer (137110)
Gregory M. Vercellotti (190593)

April 2018

<div><p>During hemolysis, hemoglobin and heme released from red blood cells promote oxidative stress...

Plasma-Derived Hemopexin as a Candidate Therapeutic Agent for Acute Vaso-Occlusion in Sickle Cell Disease: Preclinical Evidence

Thomas Gentinetta
John D. Belcher
Valérie Brügger-Verdon
Jacqueline Adam
Tanja Ruthsatz
Joseph Bain
Daniel Schu
Lisa Ventrici
Monika Edler
Hadi Lioe
Kalpeshkumar Patel
Chunsheng Chen
Julia Nguyen
Fuad Abdulla
Ping Zhang
Andreas Wassmer
Meena Jain
Marcel Mischnik
Matthias Pelzing
Kirstee Martin
Roslyn Davis
Svetlana Didichenko
Alexander Schaub
Nathan Brinkman
Eva Herzog
Adrian Zürcher
Gregory M. Vercellotti
Gregory J. Kato
Gerald Höbarth

January 2022

People living with sickle cell disease (SCD) face intermittent acute pain episodes due to vaso-occlu...

Critical Role of Hemopexin Mediated Cytoprotection in the Pathophysiology of Sickle Cell Disease

Rani Ashouri
Madison Fangman
Alicia Burris
Miriam O. Ezenwa
Diana J. Wilkie
Sylvain Doré

June 2021

Circulating hemopexin is the primary protein responsible for the clearance of heme; therefore, it is...

ApoE-/- Mice Lacking Hemopexin Develop Increased Atherosclerosis via Mechanisms That Include Oxidative Stress and Altered Macrophage Function

Thosani, Niyati Mehta

January 2015

Objective: We previously reported that Hemopexin (Hx), an acute phase protein and a heme scavenger, ...

Identification of Hemopexin as an Anti-Inflammatory Factor That Inhibits Synergy of Hemoglobin with HMGB1 in Sterile and Infectious Inflammation

Lin, Tian
Sammy, Fatima
Yang, Huan
Thundivalappil, Sujatha
Hellman, Judith
Tracey, Kevin J
Warren, H Shaw

August 2012

Hemoglobin is released from lysed RBCs in numerous clinical settings. High mobility group box 1 (HMG...

Hemopexin dosing improves cardiopulmonary dysfunction in murine sickle cell disease

Buehler, Paul W
Swindle, Delaney
Pak, David I
Ferguson, Scott k
Majka, Susan M
Karoor, Vijaya
Moldovan, Radu
Sintas, Chantal
Black, Jennifer
Gentinetta, Thomas
Buzzi, Raphael M
Vallelian, Florence
Wassmer, Andreas
Edler, Monika
Bain, Joseph
Schu, Daniel
Hassell, Kathryn
Nuss, Rachelle
Schaer, Dominik J
Irwin, David C

November 2021

Hemopexin (Hpx) is a crucial defense protein against heme liberated from degraded hemoglobin during ...

Role of hemoglobin/heme scavenger protein hemopexin in atherosclerosis and inflammatory diseases

Mehta, Niyati U
Reddy, Srinivasa T

October 2015

Purpose of reviewHemoglobin and its scavenger proteins haptoglobin and hemopexin (Hx) associate with...

Hemopexin in severe inflammation and infection: mouse models and human diseases

Lin, Tian
Maita, Dayana
Thundivalappil, Sujatha R
Riley, Frank E
Hambsch, Jasmin
Van Marter, Linda J
Christou, Helen A
Berra, Lorenzo
Fagan, Shawn
Christiani, David C
Warren, H Shaw

June 2015

Introduction: Cell-free plasma hemoglobin is associated with poor outcome in patients with sepsis. E...

MOESM1 of Annexin A5 Increases Survival in Murine Sepsis Model by Inhibiting HMGB1-Mediated Proinflammation and Coagulation

Jung Park (2351599)
Jong-Hwa Jang (5817146)
Eun Choi (3455003)
Young Kim (4006)
Eun Lee (418436)
In Jung (3414695)
Hee Han (1966600)
T-C Wu (119729)
Chien-Fu Hung (61506)
Tae Kang (3620276)
Yeong-Min Park (171090)

October 2018

Annexin A5 Increases Survival in Murine Sepsis Model by Inhibiting HMGB1-Mediated Proinflammation an...

Inhibition of Neutrophil Migration by Hemopexin Leads to Increased Mortality Due to Sepsis in Mice

SPILLER, Fernando
COSTA, Carlotta
SOUTO, Fabricio O.
VINCHI, Francesca
MESTRINER, Fabiola L. A. C.
LAURE, Helen J.
ALVES-FILHO, Jose C.
FREITAS, Andressa
ROSA, Jose C.
FERREIRA, Sergio H.
ALTRUDA, Fiorella
HIRSCH, Emilio
GREENE, Lewis J.
TOLOSANO, Emanuela
CUNHA, Fernando Q.

January 2011

Rationale: The reduction of neutrophil migration to the bacterial focus is associated with poor outc...

MOESM1 of Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of hemozoin in Suppressing Hsp70 and NF-ÎşB Activation

Prakasha Kempaiah (336992)
Karol Dokladny (695594)
Zachary Karim (3937778)
Evans Raballah (3937781)
John Ongâecha (4590142)
Pope Moseley (5816735)
Douglas Perkins (18857)

October 2018

Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of Hemozoin in Suppressing Hsp7...

Purified and Recombinant Hemopexin: Protease Activity and Effect on Neutrophil Chemotaxis

Tian Lin
Jialin Liu
Feng Huang
Tjitske S R van Engelen
Sujatha R Thundivalappil
Frank E Riley
Michael Super
Alexander L Watters
Ann Smith
Nathan Brinkman
Donald E Ingber
H Shaw Warren

January 2016

Abstract Infusion of the heme-binding protein hemopexin has been proposed as a novel approach to dec...

MOESM1 of Matrine attenuates endoplasmic reticulum stress and mitochondrion dysfunction in nonalcoholic fatty liver disease by regulating SERCA pathway

Xiaobo Gao (5998001)
Shun Guo (3606506)
Song Zhang (180477)
An Liu (291211)
Lei Shi (8144)
Yan Zhang (8098)

November 2018

Additional file 1: Figure S1. The body weight of HFD mice at 0th, 4th, 8th, and 12th. Figure S2. The...

MOESM1 of Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease

Abstract

Extracted data

MOESM1 of Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease

Abstract

Extracted data

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