Palladium-Catalyzed <i>N</i>‑Arylation of Sulfoximines with Aryl Sulfonates

Palladium-catalyzed C–N bond coupling reaction between NH-sulfoximines and aryl halides (e.g., −Br, −I, and −Cl and pseudohalides −OTf and −ONf) was successfully achieved. Nevertheless, aryl tosylates/mesylates left much to be achieved. In this report, a general N-arylation of sulfoximines with aryl sulfonates is described. Using Pd­(OAc)2/MeO-CM-phos complex, the N-aryl sulfoximine products can be obtained in good-to-excellent yields (up to 99%) with good common functional group compatibility. In addition to arene moieties, alkenyl tosylates are shown to be successful coupling partners