Dpr10 controls ORN wiring in the antennal lobe.

Mutation of dpr10 causes disruption of DM3 (A, B), V (C, D) and DL1 (E, F) glomeruli but not the VA1v (G, H) glomerulus as visualized with OR reporters diving syt::GFP (green). Disruptions to these glomeruli included splitting of the glomerulus (B, D), mistargeting (B and F, arrow) and expansion (D, arrow). Penetrance and full summary of these phenotypes are described in S5 Fig. (I-O) ORN cell bodies were visualized in heterozygous and mutant flies for Gr21a (I, J), Or47a (K, L), and Or88a (M, N) ORNs using Or-GAL4 driven UAS-mCD8::GFP. A statistically significant decrease was observed for Or47a ORNs (p0.05, O).