Relapse assessment in mice three months after completion of treatment with a combination regimen for four weeks (A) or six weeks (B).

After treatment with one of the control or test combination regimens depicted in Fig 1, both footpads of up to 10 mice per group were assessed for bacterial burden. (RIF+STR, green solid squares), (RIF+CLR, solid blue circles), (RIF+CFZ25, solid orange triangles), (RIF10+CFZ12, open orange triangles), (RIF20+CFZ12, open red squares), (RIF40+CFZ12, solid red squares), (RPT10+CFZ12, light blue diamonds), (RPT20+CFZ12, purple diamonds). Relapse proportions are indicated above each treatment group. Because gavage accidents resulted in loss of 1 mouse in the RIF10+CFZ25, and 2 mice each in the RIF20+CFZ12.5 and RIF40+CFZ12.5 groups, these mice were lost to relapse evaluation.