Summary of LTB<sub>4</sub>-promoted MRSA skin infection clearance.
- Stephanie L. Brandt (5625041)
- Nathan Klopfenstein (3044217)
- Soujuan Wang (694452)
- Seth Winfree (159016)
- Brian P. McCarthy (573009)
- Paul R. Territo (573013)
- Lloyd Miller (5625044)
- C. Henrique Serezani (694454)
Publication date
August 2018
DOI Publisher
Public Library of Science (PLoS)Abstract
Left panel: MRSA skin infection requires tissue-resident macrophages for optimal LTB4 production and neutrophil recruitment. LTB4 provides direction to neutrophils to contain bacteria and form an abscess surrounded by fibrous collagen. Middle panel: Combination ointment with LTB4 + the topical antibiotic, mupirocin, is more efficient at eliminating the infection. Right panel: Mice lacking LTB4/BLT1 fail to contain bacteria or develop an abscess. All abbreviations are defined in Figs 1 and 2 legends.</p
Add to ORKG