Minor Nortriterpenoids from the Twigs and Leaves of <i>Rhododendron latoucheae</i>
- Fei Liu (21082)
- Ya-Nan Wang (257476)
- Yong Li (15029)
- Shuang-Gang Ma (737549)
- Jing Qu (30904)
- Yun-Bao Liu (737550)
- Chang-Shan Niu (3713845)
- Zhong-Hai Tang (3137451)
- Yu-Huan Li (762877)
- Li Li (14993)
- Shi-Shan Yu (737551)
Publication date
August 2018
DOI Publisher
American Chemical Society (ACS)Abstract
A hyphenated NMR technique (analytical HPLC with a DAD connected to MS, SPE, and NMR) has proven effective for the full structural analysis and identification of minor natural products in complex mixtures. Application of this hyphenated technique to the CH2Cl2-soluble fraction of Rhododendron latoucheae led to the identification of 15 new minor ursane-type 28-nortriterpenoids (1–15). Compounds 1 and 12 inhibited HSV-1 with IC50 values of 6.4 and 0.4 μM, respectively
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